Tabbara I A, Grosh W A, Andersen W A, Taylor P T, Hahn S S, Stewart F M
University of Virginia School of Medicine, Charlottesville 22908.
Eur J Cancer. 1990;26(6):748-9. doi: 10.1016/0277-5379(90)90134-f.
Three patients with small-cell carcinoma of the cervix entered a pilot study of combination chemotherapy with agents that are not cross-resistant. Two patients had local disease and the third had extensive metastatic disease of the liver. The regimen consisted of weekly chemotherapy for 16 weeks with cisplatin, vincristine, methotrexate, doxorubicin, cyclophosphamide and etoposide followed by radiotherapy and/or surgery. The two patients with local disease achieved a pathological complete response, with no evidence of disease at 24 months and 15 months from diagnosis. The third patient achieved a partial response and is alive at 13 months with progressive disease. Side-effects were tolerable.
三名子宫颈小细胞癌患者进入了一项使用无交叉耐药性药物的联合化疗的初步研究。两名患者患有局部疾病，第三名患者患有广泛的肝转移疾病。治疗方案包括每周进行化疗，持续16周，使用顺铂、长春新碱、甲氨蝶呤、阿霉素、环磷酰胺和依托泊苷，随后进行放疗和/或手术。两名患有局部疾病的患者实现了病理完全缓解，从诊断起24个月和15个月时均无疾病证据。第三名患者实现了部分缓解，在13个月时存活，疾病进展。副作用是可耐受的。
