Lee J A, Schoener E P, Nielsen D W, Kelly A R, Lin W N, Berman R F
Department of Psychology, Wayne State University, Detroit, MI 48202.
Electroencephalogr Clin Neurophysiol. 1990 Sep-Oct;77(5):362-75. doi: 10.1016/0168-5597(90)90058-l.
A previous study found temperature-independent effects of alcohol upon the auditory brain-stem response (ABR): another found only temperature-dependent effects. To understand these paradoxical results, we measured the ABR and brain temperature in unrestrained rats before and after 3 alcohol doses (0.5, 2.5 and 5.0 g/kg). In a separate experiment, blood ethanol concentration (BEC) curves were determined for the same 3 alcohol doses. Integration of dose- and time-related effects of alcohol upon the ABR, brain temperature, and BEC suggested that alcohol has both temperature-dependent and temperature-independent effects, which vary according to dose and BEC curve phase. Temperature-dependent effects are likely during a BEC curve falling phase with a steep slope, following a high alcohol dose. Temperature-independent effects are likely during a BEC curve falling phase with a flatter slope, when BEC is still high following a moderate alcohol dose, or during a BEC curve rising phase soon after alcohol administration. The two previous studies with contradictory results each used procedural combinations likely to produce their respective results. Although both research groups administered similar alcohol doses, their alcohol solutions, administration routes, and time of ABR recording differed; consequently, they probably recorded ABR during different portions of BEC curve falling phases, which differed in slope. In view of the complex interactions among alcohol effects, BEC curve phase, temperature, and the ABR, we recommend temperature measurement during alcohol-ABR studies.
先前的一项研究发现酒精对听觉脑干反应（ABR）有与温度无关的影响；另一项研究则发现只有与温度有关的影响。为了理解这些矛盾的结果，我们在无约束的大鼠身上，于3种酒精剂量（0.5、2.5和5.0克/千克）前后测量了ABR和脑温。在另一个实验中，测定了相同3种酒精剂量的血液乙醇浓度（BEC）曲线。综合酒精对ABR、脑温和BEC的剂量和时间相关影响表明，酒精具有与温度有关和与温度无关的影响，这两种影响会根据剂量和BEC曲线阶段而有所不同。在高剂量酒精后，BEC曲线陡峭下降阶段可能会出现与温度有关的影响。在中等剂量酒精后BEC仍较高时，BEC曲线斜率较平缓的下降阶段，或者在酒精给药后不久的BEC曲线上升阶段，可能会出现与温度无关的影响。先前两项结果相互矛盾的研究各自使用的程序组合可能导致了他们各自的结果。尽管两个研究小组给予的酒精剂量相似，但他们的酒精溶液、给药途径和ABR记录时间不同；因此，他们可能在BEC曲线下降阶段的不同部分记录了ABR，而这些部分的斜率有所不同。鉴于酒精效应、BEC曲线阶段、温度和ABR之间存在复杂的相互作用，我们建议在酒精-ABR研究期间进行温度测量。
