Brus R
Arch Immunol Ther Exp (Warsz). 1975;23(4):449-57.
Activities of monoamine oxidase (MAO), DOPA-decarboxylase (DD), phenoletha-nolamine-N-methyltransferase (PNMT) and phosphodiesterase (PDE) were studied in the brain and its parts, heart, kidneys, adrenals and liver in developing rats. In vitro, the action of nialamid on MAO activity in the liver, RO-4-4602 on DD activity in the liver, and D(-) INPEA on PNMT activity in the adrenals was investigated. The influence of 6-hydroxydopamine (6-OHDA), 200 mg/kg i. p., on MAO activity in the liver of developing rats was also studied. Irregular changes in activities of examined enzymes during development were observed. 6-OHDA, nialamid and RO-4-4602 inhibited enzyme activities in young rats more strongly than in adult animals.
研究了发育中大鼠的脑及其各部分、心脏、肾脏、肾上腺和肝脏中单胺氧化酶（MAO）、多巴脱羧酶（DD）、苯乙醇胺-N-甲基转移酶（PNMT）和磷酸二酯酶（PDE）的活性。在体外，研究了尼亚酰胺对肝脏中MAO活性的作用、RO-4-4602对肝脏中DD活性的作用以及D(-)异去甲肾上腺素对肾上腺中PNMT活性的作用。还研究了腹腔注射200mg/kg的6-羟基多巴胺（6-OHDA）对发育中大鼠肝脏MAO活性的影响。观察到发育过程中所检测酶的活性有不规则变化。6-OHDA、尼亚酰胺和RO-4-4602对幼鼠酶活性的抑制作用比对成年动物更强。
