Missale G, Missale C, Sigala S, Cestari R, Memo M, Lojacono L, Spano P
Inst. of Surgical Pathology, School of Medicine, University of Brescia, Italy.
Life Sci. 1990;47(5):447-55. doi: 10.1016/0024-3205(90)90304-a.
Clinical and pharmacological evidence suggested that dopamine is involved in the control of esophageal motility. The present study was designed to determine whether or not dopamine receptors are present in human esophagus. With this aim we measured adenylate cyclase activity as a biochemical index of dopamine receptor function in esophageal specimens taken from five patients during surgery for upper esophageal carcinoma. The selective D-1 agonist fenoldopam stimulated cAMP formation in the lower esophageal sphincter, but not in the esophageal body; this effect was prevented by the selective D-1 antagonist SCH 23390 and by d-butaclamol. Bromocriptine, a selective D-2 stimulator, inhibited adenylate cyclase activity in the lower esophageal sphincter, an effect blocked by the D-2 antagonist (-)sulpiride. No effects of bromocriptine were found in the esophageal body. These data indicate that both D-1 and D-2 receptors are present in the lower esophageal sphincter, but not in esophageal body and emphasize the role of dopamine in the regulation of esophageal function.
临床和药理学证据表明，多巴胺参与食管动力的控制。本研究旨在确定人食管中是否存在多巴胺受体。为此，我们在5例上段食管癌手术患者术中获取的食管标本中，测量了腺苷酸环化酶活性，以此作为多巴胺受体功能的生化指标。选择性D-1激动剂非诺多泮可刺激食管下括约肌中cAMP的生成，但对食管体部无此作用；该效应可被选择性D-1拮抗剂SCH 23390和d-布他拉莫阻断。选择性D-2激动剂溴隐亭可抑制食管下括约肌中的腺苷酸环化酶活性，该效应可被D-2拮抗剂（-）舒必利阻断。在食管体部未发现溴隐亭的作用。这些数据表明，食管下括约肌中同时存在D-1和D-2受体，但食管体部没有，这强调了多巴胺在食管功能调节中的作用。
