Attia A M, Mostafa M H, Soliman S A, el-Sebae A H, Nonaka K O, Withyachumnarnkul B, Reiter R J
Department of Environmental Science, Institute of Graduate Studies and Research, Alexandria, Egypt.
Neurochem Res. 1990 Jul;15(7):673-80. doi: 10.1007/BF00973647.
The effect of organochlorine insecticides lindane (1,2,3,4,5,6-hexachlorocyclohexane) and DDT (1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane) were studied in terms of their effects on the rat pineal N-acetyltransferase (NAT) activity, hydroxyindole-O-methyltransferase (HIOMT) activity and pineal and serum melatonin levels during the day (2000h) and at night (2300 and 0100h). Additionally, pineal levels of 5-hydroxytryptophan (5-HTP), serotonin (5-HT), and 5-hydroxyindole acetic acid (5-HIAA) were estimated. Nocturnal NAT activity was increased after lindane administration; likewise, lindane augmented pineal and serum melatonin levels at 2300h. Conversely, DDT was without a statistically significant effect on either NAT activity or on pineal or serum melatonin levels. Neither lindane nor DDT significantly influenced pineal HIOMT values either during the day or at night. Likewise, neither insecticide consistently influenced pineal levels of either 5-HTP, 5-HT or 5-HIAA. The results indicate that the organochlorine insecticide, lindane, modifies pineal melatonin synthesis in vivo.
研究了有机氯杀虫剂林丹（1,2,3,4,5,6 - 六氯环己烷）和滴滴涕（1,1,1 - 三氯 - 2,2 - 双（对氯苯基）乙烷）对大鼠松果体N - 乙酰转移酶（NAT）活性、羟基吲哚 - O - 甲基转移酶（HIOMT）活性以及白天（20:00）和夜间（23:00和01:00）松果体和血清褪黑素水平的影响。此外，还测定了松果体中5 - 羟色氨酸（5 - HTP）、血清素（5 - HT）和5 - 羟吲哚乙酸（5 - HIAA）的水平。给予林丹后，夜间NAT活性增加；同样，林丹在23:00时提高了松果体和血清褪黑素水平。相反，滴滴涕对NAT活性或松果体或血清褪黑素水平均无统计学显著影响。林丹和滴滴涕在白天或夜间均未对松果体HIOMT值产生显著影响。同样，两种杀虫剂均未持续影响松果体中5 - HTP、5 - HT或5 - HIAA的水平。结果表明，有机氯杀虫剂林丹在体内可改变松果体褪黑素的合成。
