Mayer M
Research Institute of the Higher Nervous Activity of the Palacký University, Department of Neurobiochemistry, Olomouc, Czechoslovakia.
Acta Virol. 1990 Feb;34(1):99-107.
The leukotrienes and other lipoxygenase-derived metabolites of the arachidonic acid were proved to possess various biological activities and to participate in a number of pathological states and diseases, especially those associated with inflammatory processes and with altered immune response. The present paper reviews the role of these eicosanoids in the regulation of natural-killer cell activity and in production and action of some cytokines including interferons. Furthermore, the participation of the arachidonic acid lipoxygenase metabolism in the virus-host interaction and the relation of these findings to some experimental and human diseases is discussed.
白三烯及花生四烯酸其他脂氧合酶衍生代谢产物被证明具有多种生物活性，并参与多种病理状态和疾病，尤其是那些与炎症过程及免疫反应改变相关的疾病。本文综述了这些类二十烷酸在调节自然杀伤细胞活性以及某些细胞因子（包括干扰素）的产生和作用方面的作用。此外，还讨论了花生四烯酸脂氧合酶代谢在病毒-宿主相互作用中的参与情况，以及这些发现与一些实验性疾病和人类疾病的关系。
