Rola-Pleszczynski M
Union Med Can. 1989 May-Jun;118(3):111-3.
Leukotrienes are derived from lipoxygenation in position 5 of arachidonic acid. They have numerous biological activities, mainly in inflammatory processes. During the last few years, however, it has become quite evident that they also possess a potential for immunoregulation. In particular, LTB4 can induce suppressor cells, activate the synthesis and production of lymphokines such as interleukin 2 or interferon-gamma, stimulate the production of interleukin 1 by monocytes or macrophages, and activate cytotoxic cells against virus-infected or tumor target cells. These findings suggest that LTB4 can play an important role in the interaction between inflammatory and immune phenomena.
白三烯由花生四烯酸在5位的脂氧化作用产生。它们具有多种生物学活性，主要存在于炎症过程中。然而，在过去几年中，很明显它们也具有免疫调节潜力。特别是，白三烯B4可诱导抑制细胞，激活白细胞介素2或γ干扰素等淋巴因子的合成与产生，刺激单核细胞或巨噬细胞产生白细胞介素1，并激活针对病毒感染或肿瘤靶细胞的细胞毒性细胞。这些发现表明，白三烯B4在炎症和免疫现象之间的相互作用中可能发挥重要作用。
