Imrich Richard, Goldstein David S, Jacobowitz David M
Clinical Neurocardiology Section, NINDS/NIH, Building 10, Room 6N252, 10 Center Drive, Bethesda, MD 20892, USA.
Clin Auton Res. 2006 Dec;16(6):401-5. doi: 10.1007/s10286-006-0366-z. Epub 2006 Sep 14.
In this study we evaluated by indirect immunohistochemistry the prevalence of cerebrospinal fluid (CSF) antibodies reacting with structures of rat pons/medulla in patients with multiple system atrophy (MSA) (n = 29), Parkinson disease with neurogenic orthostatic hypotension (n = 13), or pure autonomic failure (n = 11) and in control subjects without autonomic failure (n = 33). About 10-20% of CSF samples had positive immunoreactivity to rat locus coeruleus (LC), regardless of clinical diagnosis. The results failed to confirm the previously reported high prevalence of immune binding to rat LC in CSF from patients with MSA.
在本研究中，我们通过间接免疫组织化学评估了多系统萎缩（MSA）患者（n = 29）、伴有神经源性直立性低血压的帕金森病患者（n = 13）或单纯自主神经功能衰竭患者（n = 11）以及无自主神经功能衰竭的对照受试者（n = 33）的脑脊液（CSF）抗体与大鼠脑桥/延髓结构反应的患病率。无论临床诊断如何，约10 - 20%的脑脊液样本对大鼠蓝斑（LC）具有阳性免疫反应性。结果未能证实先前报道的MSA患者脑脊液中与大鼠LC免疫结合的高患病率。
