Taylor Susan C, Burgess Cheryl M, Callender Valerie D, Fu Jan, Rendon Marta I, Roberts Wendy E, Shalita Alan R
Skin of Color Center, St. Luke's-Roosevelt Hospital Center, New York, New York, USA.
Cutis. 2006 Aug;78(2 Suppl 2):6-19.
Postinflammatory hyperpigmentation (PIH) is a common acquired excess of pigment in the epidermal and/or dermal layers of the skin. Lesions persist for extended periods if untreated, thus therapy is warranted. Topical monotherapies include the standard bleaching agent hydroquinone (HQ) as well as retinoids. Recently, several fixed-dose combination products were introduced to the armamentarium: HQ 4%-retinol 0.15% in a microsponge formulation; HQ 4%-retinol 0.3%; mequinol 2%-tretinoin (RA) 0.01%; and fluocinolone acetonide (FA) 0.01%, HQ 4%, and RA 0.05%. Recent findings have suggested that mequinol 2%-RA 0.01% solution is a promising alternative for the treatment of PIH.
炎症后色素沉着（PIH）是一种常见的后天性皮肤表皮和/或真皮层色素过度沉着。如果不进行治疗，病变会持续很长时间，因此有必要进行治疗。局部单一疗法包括标准漂白剂氢醌（HQ）以及维甲酸。最近，几种固定剂量复方产品被引入治疗手段：微海绵制剂中含4%氢醌-0.15%视黄醇；4%氢醌-0.3%视黄醇；2%甲氧基酚-0.01%维甲酸（RA）；以及0.01%醋酸氟轻松（FA）、4%氢醌和0.05% RA。最近的研究结果表明，2%甲氧基酚-0.01% RA溶液是治疗PIH的一种有前景的替代方法。
