[子宫颈细胞组织学异常女性的沙眼衣原体和乳头瘤病毒感染]

[Chlamydia trachomatis and papillomavirus infection in women with cytohistological abnormalities in uterine cervix].

作者信息

Deluca Gerardo D, Marin Héctor M, Schelover Eduardo, Chamorro Estela M, Vicente Lilian, Albhom Monica, Alonso Jose M

机构信息

Area de Biología Molecular, Instituto de Medicina Regional, Universidad Nacional del Nordeste, Resistencia, Argentina.

出版信息

Medicina (B Aires). 2006;66(4):303-6.

PMID:16977964

Abstract

The presence of Chlamydia trachomatis and human papillomavirus (HPV) was evaluated by PCR technique in 189 sexually active women, between 15 and 58 years old, with cytological abnormalities in their uterine cervical epithelium and belonging to a region of Argentina with high incidence of cervical cancer. Risk factors in relation to chlamydial infection were also analyzed. Total prevalence for C. trachomatis infection was 24.9%, but there was a significant difference between prevalence in low socio-economical level (32.9%) and high or medium socio-economical level (17.7%). Total prevalence for DNA of HPV was 52.9%, but women infected with C. trachomatis showed a higher risk for viral infection than non-infected ones (OR = 2.27 / CI 95% = 1.10-4.73), with statistical significant difference (p = 0.016).

摘要

采用聚合酶链反应（PCR）技术，对189名年龄在15至58岁之间、子宫颈上皮细胞有细胞学异常且来自阿根廷宫颈癌高发地区的性活跃女性，评估沙眼衣原体和人乳头瘤病毒（HPV）的感染情况。同时分析了与衣原体感染相关的危险因素。沙眼衣原体感染的总患病率为24.9%，但社会经济水平较低者（32.9%）与社会经济水平较高或中等者（17.7%）之间的患病率存在显著差异。HPV DNA的总患病率为52.9%，但感染沙眼衣原体的女性比未感染者表现出更高的病毒感染风险（比值比=2.27/95%置信区间=1.10 - 4.73），差异具有统计学意义（p = 0.016）。