异位促肾上腺皮质激素分泌与肿瘤
Ectopic adrenocorticotrophic hormone production and neoplasm.
作者信息
Pinerua R F, Dunn C M
出版信息
Aust N Z J Med. 1975 Jun;5(3):270-3. doi: 10.1111/j.1445-5994.1975.tb04581.x.
Abstract
Three patients presented with severe hypokalaemic, hypochloraemic alkalosis, muscle weakness and later cutaneoud pigmentation. There were few signs of Cushing's syndrome. Two had bronchial and one pancreatic neoplasm. Plasma cortisol and urinary steroid metabolites were extremely elevated and synacthen stimulation showed significant adrenal capacity even with adrenal metastases. Aminoglutethamide reduced plasma cortisol in two patients.
摘要
三名患者出现严重低钾血症、低氯性碱中毒、肌肉无力，随后出现皮肤色素沉着。库欣综合征的体征较少。两名患者患有支气管肿瘤，一名患有胰腺肿瘤。血浆皮质醇和尿类固醇代谢物极度升高，促肾上腺皮质激素刺激试验显示即使存在肾上腺转移，肾上腺功能仍显著。氨鲁米特使两名患者的血浆皮质醇降低。
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