无需采血的脑部PET-FDG动力学建模

Kinetic modeling of PET-FDG in the brain without blood sampling.

作者信息

Bentourkia M'hamed

机构信息

Department of Nuclear Medicine and Radiobiology, 3001, 12th Avenue North, University of Sherbrooke, Sherbrooke, QC J1H 5N4, Canada.

出版信息

Comput Med Imaging Graph. 2006 Dec;30(8):447-51. doi: 10.1016/j.compmedimag.2006.07.002. Epub 2006 Sep 15.

DOI:10.1016/j.compmedimag.2006.07.002

PMID:16978837

Abstract

The aim in this work is to report a new method to calculate parametric images from a single scan acquisition with positron emission tomography (PET) and fluorodeoxyglucose (FDG) in the human brain without blood sampling. It is usually practical for research or clinical purposes to inject the patient in an isolated room and to start the PET acquisition only for some 10-20 min, about 30 min after FDG injection. In order to calculate the cerebral metabolic rates for glucose (CMRG), usually several blood samples are required. The proposed method considers the relation between the uptake of the tracer in the cerebellum as a reference tissue and the population based input curve. Similar results were obtained for CMRG values with the present method in comparison to the usual autoradiographic and the non-linear least squares fitting of regions of interest.

摘要

这项工作的目的是报告一种新方法，该方法可在不进行血液采样的情况下，通过正电子发射断层扫描（PET）和氟脱氧葡萄糖（FDG）对人脑进行单次扫描采集来计算参数图像。对于研究或临床目的而言，通常的做法是在隔离房间为患者注射药物，并且仅在注射FDG约30分钟后开始进行约10 - 20分钟的PET采集。为了计算脑葡萄糖代谢率（CMRG），通常需要采集多个血样。所提出的方法考虑了作为参考组织的小脑对示踪剂的摄取与基于群体的输入曲线之间的关系。与通常的放射自显影法和感兴趣区域的非线性最小二乘拟合相比，用本方法获得的CMRG值结果相似。