Darbin Olivier, Carre Emily, Naritoku Dean, Risso Jean Jacque, Lonjon Michel, Patrylo Peter R
Department of Physiology, Southern Illinois University School of Medicine, Carbondale, IL 62901, USA.
Brain Res. 2006 Oct 20;1116(1):127-31. doi: 10.1016/j.brainres.2006.06.095. Epub 2006 Sep 15.
The outcome of patients with traumatic brain injury (TBI) can be predicted by the extracellular potassium concentration and the change in energy homeostasis. In this study, the authors investigated the effects of high potassium concentrations on extracellular levels of glucose, pyruvate and lactate in the rat striatum. Applying artificial cerebrospinal fluid (ACSF) enriched with 120 mM potassium by reverse microdialysis leads to an increase in lactate and reduction in glucose and pyruvate. Consequently, the lactate to pyruvate ratio was also increased. These data are discussed in the context of recent studies on lactate/pyruvate conversion and the potential mechanisms whereby high potassium could affect this equilibrium. We conclude that ischemic-like events are unlikely to explain these K(+)-induced changes.
创伤性脑损伤（TBI）患者的预后可通过细胞外钾浓度和能量稳态变化来预测。在本研究中，作者调查了高钾浓度对大鼠纹状体细胞外葡萄糖、丙酮酸和乳酸水平的影响。通过反向微透析应用富含120 mM钾的人工脑脊液（ACSF）会导致乳酸增加，葡萄糖和丙酮酸减少。因此，乳酸与丙酮酸的比值也会增加。这些数据在近期关于乳酸/丙酮酸转化以及高钾可能影响这种平衡的潜在机制的研究背景下进行了讨论。我们得出结论，类似缺血的事件不太可能解释这些钾离子诱导的变化。
