Strohmaier W L, Bichler K H, Flüchter S H, Wilbert D M
Department of Urology, University of Tübingen Medical School, Federal Republic of Germany.
J Urol. 1990 Oct;144(4):913-7. doi: 10.1016/s0022-5347(17)39621-0.
Recently, hyperthermia has been used for treatment of benign prostatic hyperplasia. The preliminary results reported were promising. However, apart from patients with total urinary retention, objective voiding parameters have not been reported in detail for patients with prostatism. In a phase II study we treated 30 patients with benign prostatic hyperplasia by local microwave hyperthermia (915 MHz.). The prostate was heated transrectally to 42 to 43C, with the treatment consisting of 8 sessions of 60 minutes each given twice a week. To assess the results of treatment several parameters were determined before and 4 weeks after hyperthermia therapy, including transrectal ultrasound of the prostate with volumetry, urinary flow rate and residual volume. Of the patients 28 could be evaluated and only 2 showed a relevant improvement. Neither the voiding parameters nor the size of the prostate could be changed significantly by hyperthermia. The success rate of 7.1% is even lower than the spontaneous temporary regression rate of benign prostatic hyperplasia. Thus, we believe that hyperthermia cannot be regarded as an effective treatment for benign prostatic hyperplasia comparable to transurethral resection.
最近，热疗已被用于治疗良性前列腺增生。报告的初步结果很有前景。然而，除了完全尿潴留患者外，对于前列腺增生患者，客观排尿参数尚未详细报道。在一项II期研究中，我们用局部微波热疗（915兆赫）治疗了30例良性前列腺增生患者。经直肠将前列腺加热至42至43摄氏度，治疗包括每周两次，每次8节，每节60分钟。为了评估治疗结果，在热疗前和热疗后4周测定了几个参数，包括经直肠超声测量前列腺体积、尿流率和残余尿量。28例患者可进行评估，只有2例有明显改善。热疗既不能显著改变排尿参数，也不能显著改变前列腺大小。7.1%的成功率甚至低于良性前列腺增生的自发暂时缓解率。因此，我们认为热疗不能被视为一种与经尿道切除术相当的有效治疗良性前列腺增生的方法。
