Anderson Nora, Borlak Jürgen
Medical School of Hannover, Center for Pharmacology and Toxicology, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.
FEBS Lett. 2006 Oct 9;580(23):5533-40. doi: 10.1016/j.febslet.2006.08.061. Epub 2006 Sep 5.
Drug-induced phospholipidosis is characterized by intracellular accumulation of phospholipids with lamellar bodies, most likely from an impaired phospholipid metabolism of the lysosome. Organs affected by phospholipidosis exhibit inflammatory reactions and histopathological changes. Despite significant advances in the understanding of drug-altered lipid metabolism, the relationship between impaired phospholipid metabolism and drug-induced toxicity remains enigmatic. Here we review molecular features of inheritable lysosomal storage disorders as a molecular mimicry of drug-induced phospholipidosis for an improved understanding of adverse drug reaction.
药物性磷脂沉积症的特征是细胞内出现含有板层小体的磷脂蓄积，这很可能源于溶酶体磷脂代谢受损。受磷脂沉积症影响的器官会出现炎症反应和组织病理学变化。尽管在理解药物改变的脂质代谢方面取得了重大进展，但磷脂代谢受损与药物诱导毒性之间的关系仍然不明。在此，我们综述可遗传性溶酶体贮积症的分子特征，将其作为药物性磷脂沉积症的分子模拟，以增进对药物不良反应的理解。
