Tashiro Y, Watanabe Y, Enomoto Y
Acta Pathol Jpn. 1983 Sep;33(5):929-42.
The effect of a generalized phospholipidosis inducing drug, diethylamino-ethoxyhexestrol (DH, a coronary vasodilator), was studied using rats. The initial alterations are characterized by the appearance of abnormal cytoplasmic inclusion bodies. At the early stage of DH administration, they appeared near the Golgi apparatus. Histochemical and ultrastructural evidence showed that the inclusion bodies consisted of polar lipid, mainly of phospholipids. From cytochemical and biochemical observation, the lysosome was regarded as the primary site of the drug-induced morphological changes. The drug-induced abnormal cytoplasmic inclusion bodies were of three basic morphological types, i.e., multilamellated, crystalloid and finger-print-like bodies. Additionally, many intermediate forms were found showing structural features of those basic types. These drug-induced cytoplasmic changes, namely storage of phospholipids, were considered to be reversible both morphologically and biochemically after the cessation of DH administration.
使用大鼠研究了一种可诱导全身性磷脂沉积症的药物——二乙氨基乙氧基己烯雌酚（DH，一种冠状血管扩张剂）的作用。最初的改变表现为出现异常的细胞质包涵体。在给予DH的早期阶段，它们出现在高尔基体附近。组织化学和超微结构证据表明，包涵体由极性脂质组成，主要是磷脂。从细胞化学和生物化学观察来看，溶酶体被认为是药物诱导形态变化的主要部位。药物诱导的异常细胞质包涵体有三种基本形态类型，即多层状、晶体状和指纹状小体。此外，还发现了许多显示出这些基本类型结构特征的中间形式。这些药物诱导的细胞质变化，即磷脂的储存，在停止给予DH后被认为在形态和生化方面都是可逆的。
