Toshkova R A, Krasteva I N, Wesselinova D W, Nikolov S D
Department of Immunology, Institute of Experimental Pathology and Parasitology, BAS, G. Bonchev Street, Bl. 25, 1113 Sofia, Bulgaria.
J Ethnopharmacol. 2007 Feb 12;109(3):394-9. doi: 10.1016/j.jep.2006.08.006. Epub 2006 Aug 17.
A purified saponin mixture (PSM) from Astragalus corniculatus Bieb. protected significantly hamsters against the experimental Graffi myeloid tumor. The application of PSM increased the survival rates, prolonged mean survival time and the tumor growth was markedly reduced. A purified saponin mixture (PSM) of Astragalus corniculatus Bieb. was evaluated for its immunostimulating potentials on the phagocytic cells in Graffi-tumor bearing hamsters. The number, migration and phagocytic indexes of peritoneal macrophages (pMøs) and of blood polymorphonuclear leukocytes (PMNs) were evaluated in healthy and Graffi-tumor bearing hamsters (G-TBH) treated with PSM. It was established that the Graffi myeloid tumor induced suppression of the phagocytic abilities of pMøs and PMNs. The number and migration of pMøs was significantly decreased during the whole period of observation. All tested parameters-number, migration and phagocytic activities of pMøs, as well as phagocytic ability of PMNs increased significantly in healthy and G-TBH after i.p. application of the 50 mg/kg body weight PSM. The PMS extracts from Astragalus corniculatus Bieb. are isolated and examined and their immunostimulating and immunorestorating impact on phagocitic cells was proven for the first time. This effect could be due to their high content of purified saponins.
来自角果黄耆的纯化皂苷混合物（PSM）能显著保护仓鼠抵御实验性格拉菲髓细胞瘤。PSM的应用提高了存活率，延长了平均存活时间，且肿瘤生长明显减缓。对角果黄耆的纯化皂苷混合物（PSM）在荷格拉菲瘤仓鼠的吞噬细胞上的免疫刺激潜力进行了评估。在用PSM处理的健康和荷格拉菲瘤仓鼠（G-TBH）中，评估了腹膜巨噬细胞（pMøs）和血液多形核白细胞（PMNs）的数量、迁移和吞噬指数。结果表明，格拉菲髓细胞瘤会抑制pMøs和PMNs的吞噬能力。在整个观察期内，pMøs的数量和迁移显著减少。在腹腔注射50mg/kg体重的PSM后，健康和G-TBH仓鼠的所有测试参数——pMøs的数量、迁移和吞噬活性以及PMNs的吞噬能力均显著增加。首次对角果黄耆的PMS提取物进行了分离和检测，并证实了其对吞噬细胞的免疫刺激和免疫恢复作用。这种作用可能归因于其高含量的纯化皂苷。
