Nicolaidis Stylianos
Centre National de Recherche Scientifique (CNRS) of the Collège de France, Paris 5, France.
Metabolism. 2006 Oct;55(10 Suppl 2):S24-9. doi: 10.1016/j.metabol.2006.07.009.
The concurrent background level of metabolic activity may control state of vigilance, promoting wakefulness (and hunger) when it is low, or sleep (and satiety) when it is high. In a series of experiments, we have shown that sleep is dependent on feeding, but only because of the metabolic consequences of food ingestion. These consequences are sensed by glioneuronal populations (at least in the rostromedial hypothalamus), which probably respond to channel-bound adenosine triphosphate/diphosphate turnover (ischymetric monitoring) rather than to the binding of such downstream molecules as adenosine and cytochrome c oxidase. This basic signal is communicated to the vigilance-controlling centers by a cascade of peptidic and nonpeptidic messengers-messengers that promote wakefulness and hunger, possibly via a hypometabolic action (as in the case of neuropeptide Y or hypocretins), or somnolence and satiety, possibly via a hypermetabolic action (as in the case of leptin or certain serotonergic agents).
代谢活动的并发背景水平可能控制警觉状态，在其水平较低时促进清醒（和饥饿），在其水平较高时促进睡眠（和饱腹感）。在一系列实验中，我们已经表明睡眠依赖于进食，但这仅仅是由于食物摄入的代谢后果。这些后果由神经胶质神经元群体（至少在 Rostromedial 下丘脑）感知，它们可能对通道结合的三磷酸腺苷/二磷酸周转（等容监测）做出反应，而不是对腺苷和细胞色素 c 氧化酶等下游分子的结合做出反应。这个基本信号通过一系列肽类和非肽类信使传递到警觉控制中心，这些信使促进清醒和饥饿，可能通过低代谢作用（如神经肽 Y 或下丘脑分泌素的情况），或者促进嗜睡和饱腹感，可能通过高代谢作用（如瘦素或某些血清素能药物的情况）。
