International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki, Japan.
Doctoral Program in Sports Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan.
Sci Rep. 2021 Sep 8;11(1):17849. doi: 10.1038/s41598-021-97301-8.
Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
氧化底物被选择用于响应营养状态的变化，这被称为代谢灵活性。睡眠会导致长时间的禁食，因此人们假设，在睡眠期间，氧化底物会逐渐从碳水化合物转向脂肪，从而逐渐降低呼吸商（RQ）。然而，与这一假设相反，具有更高时间分辨率的整个房间间接测热法显示，RQ 在醒来前再次上升，并且在睡前，非肥胖的年轻成年人的 RQ 最低点女性早于男性。在代谢灵活性较低的男性中，RQ 的短暂下降减弱，其 RQ 的昼夜节律幅度较小。同样，年龄差异对 RQ 的影响在睡眠期间变得显著；在睡眠期间，RQ 的下降减弱。在睡眠期间，RQ 的个体差异变得明显，它可能成为深入了解代谢灵活性早期发病机制的窗口。
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