Wong Jeffrey Y C
Division of Radiation Oncology, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA, USA.
Int J Radiat Oncol Biol Phys. 2006;66(2 Suppl):S8-14. doi: 10.1016/j.ijrobp.2005.05.056.
Antibody targeted radiotherapy brings an important new treatment modality to the radiation oncology clinic. Radiation dose to tumor and normal tissues are determined by a complex interplay of antibody, antigen, tumor, radionuclide, and host-related factors. A basic understanding of these immunologic and physiologic factors is important to optimally utilize this therapy in the clinic. Preclinical and clinical studies need to be continued to broaden our understanding and to develop new strategies to further improve the efficacy of this promising form of targeted therapy.
抗体靶向放疗为放射肿瘤学临床带来了一种重要的新治疗方式。肿瘤和正常组织所接受的辐射剂量取决于抗体、抗原、肿瘤、放射性核素及宿主相关因素之间复杂的相互作用。对这些免疫和生理因素有基本的了解，对于在临床中最佳地利用这种治疗方法很重要。需要继续开展临床前和临床研究，以拓宽我们的认识，并制定新策略来进一步提高这种有前景的靶向治疗形式的疗效。
