Tekdogan Umit, Tuncel Altug, Tuglu Devrim, Basar M Murad, Atan Ali
Third Department of Urology, Ministry of Health, Ankara Numune Research and Training Hospital, Ankara, Turkey.
Urology. 2006 Sep;68(3):626-30. doi: 10.1016/j.urology.2006.03.019. Epub 2006 Sep 18.
To investigate the effect of sildenafil citrate treatment on serum dehydroepiandrosterone sulfate (DHEAS) levels in patients with erectile dysfunction (ED).
A total of 124 men with a mean age of 45.9 years were included in the study. Group 1 consisted of 78 patients with ED, as determined by the Sexual Health Inventory of Male (SHIM) scale (score less than 21). Group 2 consisted of 46 healthy men with a SHIM score of 21 or greater. The 78 patients with ED took 100 mg sildenafil citrate at least eight times in 1 month. The SHIM scale was administered and serum DHEAS levels measured before and after treatment in the ED group. The serum DHEAS levels were also measured in the control group. The treatment response was defined as positive if the SHIM score was 21 or greater after sildenafil administration.
At the end of sildenafil citrate treatment, the serum DHEAS levels and SHIM scores had increased significantly in the ED group (P = 0.013 and P = 0.001, respectively). In groups 1 and 2, the mean pretreatment serum DHEAS level of the men younger than 50 years old was 200.1 +/- 77.9 and 279.4 +/- 125.4 microg/dL, respectively (P = 0.013). The elevation of the serum DHEAS levels and SHIM scores was more significant in the sildenafil responders (P = 0.002 and P = 0.001), respectively.
Serum DHEAS levels were significantly greater in the patients younger than 50 years old than in the older patients in the ED group. The serum DHEAS levels increased significantly after sildenafil citrate treatment in the ED group (especially in the younger men). Also, patient age was an important factor affecting the sildenafil citrate response.
探讨枸橼酸西地那非治疗对勃起功能障碍（ED）患者血清硫酸脱氢表雄酮（DHEAS）水平的影响。
本研究共纳入124名平均年龄为45.9岁的男性。第1组由78例经男性性健康量表（SHIM）评分（得分低于21分）确诊为ED的患者组成。第2组由46名SHIM评分为21分或更高的健康男性组成。78例ED患者在1个月内至少服用100mg枸橼酸西地那非8次。对ED组患者在治疗前后进行SHIM量表评估并测量血清DHEAS水平。同时也测量了对照组的血清DHEAS水平。若服用西地那非后SHIM评分为21分或更高，则将治疗反应定义为阳性。
枸橼酸西地那非治疗结束时，ED组患者的血清DHEAS水平和SHIM评分均显著升高（分别为P = 0.013和P = 0.001）。在第1组和第2组中，年龄小于50岁男性的治疗前血清DHEAS平均水平分别为200.1±77.9和279.4±125.4μg/dL（P = 0.013）。西地那非治疗有反应者的血清DHEAS水平和SHIM评分升高更为显著（分别为P = 0.002和P = 0.001）。
ED组中年龄小于50岁的患者血清DHEAS水平显著高于年龄较大的患者。ED组患者在枸橼酸西地那非治疗后血清DHEAS水平显著升高（尤其是年轻男性）。此外，患者年龄是影响枸橼酸西地那非治疗反应的重要因素。
