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本文引用的文献

1
Cytokine profiling for prediction of symptomatic radiation-induced lung injury.用于预测放射性肺炎症状的细胞因子分析
Int J Radiat Oncol Biol Phys. 2005 Dec 1;63(5):1448-54. doi: 10.1016/j.ijrobp.2005.05.032. Epub 2005 Aug 22.
2
Time course of serum cytokines in patients receiving proton or combined photon/proton beam radiation for resectable but medically inoperable non-small-cell lung cancer.接受质子或光子/质子联合束放疗的可切除但医学上无法手术的非小细胞肺癌患者血清细胞因子的时间进程。
Int J Radiat Oncol Biol Phys. 2004 Nov 1;60(3):759-66. doi: 10.1016/j.ijrobp.2004.04.022.
3
Transforming growth factor-beta plasma dynamics and post-irradiation lung injury in lung cancer patients.肺癌患者中转化生长因子-β的血浆动力学及放疗后肺损伤
Radiother Oncol. 2004 May;71(2):183-9. doi: 10.1016/j.radonc.2004.01.019.
4
Significance of plasma transforming growth factor-beta levels in radiotherapy for non-small-cell lung cancer.血浆转化生长因子-β水平在非小细胞肺癌放射治疗中的意义
Int J Radiat Oncol Biol Phys. 2004 Apr 1;58(5):1378-87. doi: 10.1016/j.ijrobp.2003.09.078.
5
Increased IL-6 and TGF-beta1 concentrations in bronchoalveolar lavage fluid associated with thoracic radiotherapy.与胸部放疗相关的支气管肺泡灌洗液中白细胞介素-6和转化生长因子-β1浓度升高。
Int J Radiat Oncol Biol Phys. 2004 Mar 1;58(3):758-67. doi: 10.1016/S0360-3016(03)01614-6.
6
Gene expression of transforming growth factor beta receptors I and II in non-small-cell lung tumors.非小细胞肺癌中转化生长因子β受体I和II的基因表达
Cytokine. 2003 Dec 7;24(5):182-9. doi: 10.1016/j.cyto.2003.08.008.
7
Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury.细胞外超氧化物歧化酶的过表达可保护小鼠免受辐射诱导的肺损伤。
Int J Radiat Oncol Biol Phys. 2003 Nov 15;57(4):1056-66. doi: 10.1016/s0360-3016(03)01369-5.
8
Risk of long-term complications after TFG-beta1-guided very-high-dose thoracic radiotherapy.转化生长因子-β1 引导下的超高剂量胸部放疗后长期并发症的风险
Int J Radiat Oncol Biol Phys. 2003 Jul 15;56(4):988-95. doi: 10.1016/s0360-3016(03)00184-6.
9
Comparing different NTCP models that predict the incidence of radiation pneumonitis. Normal tissue complication probability.比较不同的预测放射性肺炎发生率的正常组织并发症概率（NTCP）模型。
Int J Radiat Oncol Biol Phys. 2003 Mar 1;55(3):724-35. doi: 10.1016/s0360-3016(02)03986-x.
10
Dose-volume factors contributing to the incidence of radiation pneumonitis in non-small-cell lung cancer patients treated with three-dimensional conformal radiation therapy.三维适形放射治疗的非小细胞肺癌患者中，剂量体积因素对放射性肺炎发生率的影响
Int J Radiat Oncol Biol Phys. 2002 Oct 1;54(2):329-39. doi: 10.1016/s0360-3016(02)02929-2.

转化生长因子-β1能否预测肺癌治疗患者的放射性肺炎？

Does transforming growth factor-beta1 predict for radiation-induced pneumonitis in patients treated for lung cancer?

作者信息

Evans Elizabeth S, Kocak Zafer, Zhou Su-Min, Kahn Daniel A, Huang Hong, Hollis Donna R, Light Kim L, Anscher Mitchell S, Marks Lawrence B

机构信息

Department of Radiation Oncology, Duke University Medical Center, Box 3085, Durham, NC 27710, USA.

出版信息

Cytokine. 2006 Aug;35(3-4):186-92. doi: 10.1016/j.cyto.2006.07.021. Epub 2006 Sep 18.

DOI:10.1016/j.cyto.2006.07.021
PMID:16979900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1829192/
Abstract

The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpoint of grade > or =1 RP, those with V30>30% and an end-RT/baseline TGF-beta1 ratio> or =1 had a significantly higher incidence of RP than did those with V30>30% and an end-RT/baseline TGF-beta1 ratio<1. For most other patient groups, there were no clear associations between TGF-beta1 values and rates of RP. These findings suggest that TGF-beta1 is generally not predictive for RP except for the group of patients with a high V30.

摘要

本研究的目的是重新评估转化生长因子-β1（TGF-β1）联合剂量学和肿瘤参数作为放射性肺炎（RP）预测指标的效用。在121例研究患者中，32例（26.4%）发生≥1级RP，27例（22.3%）发生≥2级RP。对于≥1级RP这一终点，V30>30%且放疗结束时/基线TGF-β1比值≥1的患者RP发生率显著高于V30>30%且放疗结束时/基线TGF-β1比值<1的患者。对于大多数其他患者组，TGF-β1值与RP发生率之间没有明确关联。这些发现表明，除了V30较高的患者组外，TGF-β1一般不能预测RP。