Logan Richard M, Gibson Rachel J, Sonis Stephen T, Keefe Dorothy M K
Oral Pathology, School of Dentistry, The University of Adelaide, Adelaide, North Terrace, SA 5005, Australia.
Oral Oncol. 2007 Apr;43(4):395-401. doi: 10.1016/j.oraloncology.2006.04.011. Epub 2006 Sep 18.
Oral mucositis is a serious and debilitating side effect of cancer treatment. Greater understanding of the pathobiology of mucositis has recently led to the advent of targeted treatments for specific patient populations; however the treatment for mucositis remains palliative for most patients. Nuclear factor-kappaB (NF-kappaB) and cyclooxygenase 2 (COX-2) are thought to play important roles in the development of mucositis. In this study, 20 patients undergoing cytotoxic chemotherapy had oral mucosal biopsies taken prior to and following administration of cytotoxic chemotherapy. The samples were stained for NF-kappaB and COX-2 using routine immunohistochemistry. The results from this preliminary study demonstrated statistically significant increased oral mucosal staining for NF-kappaB and COX-2 following cytotoxic chemotherapy and provide further support for the role of NF-kappaB and COX-2 in the pathogenesis of mucositis.
口腔黏膜炎是癌症治疗中一种严重且使人虚弱的副作用。最近对黏膜炎病理生物学的深入了解促使针对特定患者群体的靶向治疗出现；然而，对于大多数患者来说，黏膜炎的治疗仍然是姑息性的。核因子-κB（NF-κB）和环氧化酶2（COX-2）被认为在黏膜炎的发生发展中起重要作用。在本研究中，20例接受细胞毒性化疗的患者在接受细胞毒性化疗之前和之后进行了口腔黏膜活检。使用常规免疫组织化学对样本进行NF-κB和COX-2染色。这项初步研究的结果表明，细胞毒性化疗后口腔黏膜NF-κB和COX-2染色在统计学上显著增加，并为NF-κB和COX-2在黏膜炎发病机制中的作用提供了进一步支持。
