Calnek B W, Higgins D A, Fabricant J
Avian Dis. 1975 Jul-Sep;19(3):473-82.
In 4 experiments, strains of chickens relatively susceptible (S-strain, P-line) or resistant (N-line, PDRC) to Marek's disease (MD) were challenged with Rous sarcoma virus (RSV) at 6-8 weeks old. RSV tumors occurred in 94-100% of the birds in each strain, but the number with tumors that regressed during the 40-46-day experiment varied from 7% (S-strain) to 91% (PDRC). The N-line and P-line birds, derived from a random-bred flock with selection only for susceptibility or resistance to MD, regressed their tumors at about equal rates (respectively 59 and 65%). Thus, although the genetic strains differed in ability to regress RSV tumors, the difference was not necessarily related to genetic resistance or susceptibility to MD. Other birds in 2 of the experiments, infected 2-4 weeks earlier with JM or GA isolants of MD virus, had significantly (P less than 0.01) lower incidence of RSV tumor regression than did controls provided that they developed gross lesions of MD.
在4项实验中，对6至8周龄的对马立克氏病（MD）相对易感（S品系、P系）或抗性（N系、PDRC）的鸡品系用劳斯肉瘤病毒（RSV）进行攻毒。在每个品系中，94%至100%的鸡出现了RSV肿瘤，但在40至46天的实验期间肿瘤消退的鸡的数量从7%（S品系）到91%（PDRC）不等。N系和P系鸡来自一个仅对MD的易感性或抗性进行选择的随机繁殖鸡群，它们的肿瘤消退率大致相同（分别为59%和65%）。因此，尽管这些遗传品系在RSV肿瘤消退能力上存在差异，但这种差异不一定与对MD的遗传抗性或易感性相关。在其中2项实验中的其他鸡，在2至4周前用MD病毒的JM或GA分离株感染，如果它们出现了MD的肉眼病变，则RSV肿瘤消退的发生率显著低于对照组（P<0.01）。
