Fabricant J, Calnek B W, Schat K A, Murthy K K
Avian Dis. 1978 Oct-Dec;22(4):646-58.
This study compares the ability of strains of chickens of varied genetic resistance to Marek's disease (MD) to resist or regress both local and general reactions to transplantable tumor cells induced by a variety of MD virus strains and to transmissible lymphoid tumor cells (Olson's TLT) induced by an avian leukosis-sarcoma retrovirus. Previous studies have dealt with only a single MD transplant. Three conclusions can be drawn from our data: 1) MD virus infection alone could induce progressive tumors at the site of inoculation. 2) Progression or regression of transplant tumors was independent of genetic susceptibility to MD. 3) Incidence of virus-induced host tumors was dependent upon genetic susceptibility to MD.
本研究比较了对马立克氏病（MD）具有不同遗传抗性的鸡品系，抵抗或消退由多种MD病毒株诱导的可移植肿瘤细胞以及由禽白血病-肉瘤逆转录病毒诱导的传染性淋巴样肿瘤细胞（奥尔森氏TLT）所引发的局部和全身反应的能力。以往的研究仅涉及单一的MD移植。从我们的数据中可以得出三个结论：1）单独的MD病毒感染可在接种部位诱发进行性肿瘤。2）移植肿瘤的进展或消退与对MD的遗传易感性无关。3）病毒诱导的宿主肿瘤的发生率取决于对MD的遗传易感性。
