Tabuchi Keiji, Murashita Hidekazu, Sakai Shuhei, Hoshino Tomofumi, Uemaetomari Isao, Hara Akira
Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan.
Otol Neurotol. 2006 Dec;27(8):1176-9. doi: 10.1097/01.mao.0000226313.82069.3f.
This study aims to investigate the therapeutic time window of methylprednisolone in acoustic injury.
Although glucocorticoids have been widely used in the treatment of acoustic injury, the therapeutic time window of glucocorticoids in acoustic injury has never been examined.
Mice were exposed to 4-kHz pure tone of 128-dB sound pressure level for 4 hours. Auditory brainstem response was examined before, immediately after, and 2 weeks after acoustic overexposure.
Methylprednisolone significantly improved the auditory brainstem response threshold shifts 2 weeks after acoustic overexposure when it was administered before or immediately after acoustic overexposure, but not when administered 3 hours after acoustic overexposure.
The present findings suggest that methylprednisolone possesses protective effects against acoustic injury of the cochlea with a short therapeutic time window.
本研究旨在探讨甲基强的松龙治疗声损伤的时间窗。
尽管糖皮质激素已广泛应用于声损伤的治疗，但糖皮质激素治疗声损伤的时间窗从未被研究过。
将小鼠暴露于128分贝声压级的4千赫纯音下4小时。在声过度暴露前、暴露后即刻以及暴露后2周检测听觉脑干反应。
在声过度暴露前或暴露后即刻给予甲基强的松龙，可显著改善暴露后2周时的听觉脑干反应阈值偏移，但在声过度暴露后3小时给予则无此效果。
目前的研究结果表明，甲基强的松龙对耳蜗声损伤具有保护作用，且治疗时间窗较短。
