Sakat Muhammed Sedat, Kilic Korhan, Bercin Sami
Department of Otorhinolaryngology, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Palandoken State Hospital, Otolaryngology Clinics, Erzurum, Turkey.
Eur Arch Otorhinolaryngol. 2016 Dec;273(12):4089-4101. doi: 10.1007/s00405-016-3936-2. Epub 2016 Feb 16.
Noise is a stress factor that causes auditory, psychological and physiological effects. The realization that sudden loud noises or chronic exposure to noise in social and working environments can cause hearing loss has led to increased interest in noise-induced hearing loss (NIHL). The best means of preventing primary damage is protection against noise. Since this protection is not always possible for various reasons, the use of pharmacological agents to prevent or treat NIHL should also be considered. The purpose of this study is to discuss current pharmacological protection and treatment options in the light of the literature, since no such extensive reviews have been performed to date, including agents used for protection against and treatment of NIHL. We reviewed both animal and clinical studies, and these are discussed separately for ease of comprehension. For each agent, first animal studies, then clinical studies, if available, are discussed. We also performed a two-step search of the literature. In the first step, we searched the terms "noise induced hearing loss", "treatment" and "protection" in Pubmed. Based on the results obtained, we identified the agents used for the treatment of and protection against NIHL. In the second step, we searched the names of the agents identified in the first step, together with the term "noise induced hearing loss," and reviewed the results.
噪声是一种会导致听觉、心理和生理影响的应激因素。人们认识到，突然的巨响或在社交和工作环境中长期接触噪声会导致听力损失，这使得人们对噪声性听力损失（NIHL）的关注度不断提高。预防原发性损伤的最佳方法是进行噪声防护。由于各种原因，这种防护并非总是可行，因此还应考虑使用药物制剂来预防或治疗NIHL。本研究的目的是根据文献讨论当前的药物防护和治疗选择，因为迄今为止尚未进行过如此广泛的综述，包括用于预防和治疗NIHL的药物。我们回顾了动物研究和临床研究，为便于理解，将分别进行讨论。对于每种药物，首先讨论动物研究，然后如果有临床研究的话，再进行讨论。我们还对文献进行了两步检索。第一步，我们在PubMed中搜索了“噪声性听力损失”“治疗”和“防护”等术语。根据获得的结果，我们确定了用于治疗和预防NIHL的药物。第二步，我们搜索了第一步中确定的药物名称以及“噪声性听力损失”一词，并对结果进行了综述。
