Málaga Ignacio, Sanmarti Francesc X
Department of Pediatric Neurology, Hospital Universitario Sant Joan de Deu, Barcelona, Spain.
Epilepsia. 2006 Sep;47(9):1576-9. doi: 10.1111/j.1528-1167.2006.00713.x.
We report two patients with refractory epilepsy who developed unilateral painful gynecomastia and lower extremity pain (one of them localized and the other one diffuse), shortly after receiving Pregabalin (PGB). Neither of them had previous endocrinologic problems or complaints about pain on their medical history. PGB was stopped in one patient and reduced in the other one, with complete disparition of the symptoms in the following weeks in both patients. This supports the hypothesis that gynecomastia could be a drug-induced and easy to manage secondary effect of PGB, with a higher incidence than observed on previous clinical trials.
我们报告了两名难治性癫痫患者，他们在服用普瑞巴林（PGB）后不久出现了单侧疼痛性乳腺增生和下肢疼痛（其中一名患者疼痛局限，另一名患者疼痛弥漫）。他们既往均无内分泌问题，病史中也无疼痛相关主诉。一名患者停用了PGB，另一名患者减少了剂量，两名患者在接下来的几周内症状均完全消失。这支持了以下假设：乳腺增生可能是PGB引起的药物性继发效应，且易于处理，其发生率高于既往临床试验观察到的情况。
