Browne D L, Meeking D R, Allard S, Munday L J, Shaw K M, Cummings M H
Academic Department of Diabetes and Endocrinology, Queen Alexandra Hospital, Cosham, Portsmouth PO6 3LY, UK.
Int J Clin Pract. 2006 Oct;60(10):1323-6. doi: 10.1111/j.1742-1241.2006.01076.x.
Erectile dysfunction (ED) affects up to 70% of men with diabetes. However, the pathophysiology of ED in diabetes remains uncertain with both neuronal and vascular factors cited. We examined whether ED is an indicator of generalized endothelial dysfunction. A unique group of diabetic patients free from established conventional cardiac risk factors were investigated. Forearm bloodflow responses to nitroprusside and acetylcholine on 11 diabetic men with ED and 11 potent diabetic men were measured by venous plethysmography. Patient characteristics between the impotent and potent patients were similar except for Hba1c which was higher in the group with ED (8.35% vs. 7.03%: p = 0.003). Both groups showed increases in FBF to incremental infusions of nitroprusside and acetylcholine but the area under curve (AUC) were similar in the ED and the non-ED groups (p = 0.16 and p = 0.17, respectively). We demonstrated that ED in patients with type 2 diabetes is not associated with additional generalized endothelial dysfunction.
勃起功能障碍（ED）影响多达70%的糖尿病男性患者。然而，糖尿病性ED的病理生理学仍不明确，神经和血管因素均被提及。我们研究了ED是否是全身性内皮功能障碍的一个指标。我们对一组无传统既定心脏危险因素的独特糖尿病患者进行了调查。通过静脉体积描记法测量了11名患有ED的糖尿病男性和11名性功能正常的糖尿病男性对硝普钠和乙酰胆碱的前臂血流反应。除糖化血红蛋白（Hba1c）外，阳痿患者和性功能正常患者的患者特征相似，ED组的Hba1c更高（8.35%对7.03%：p = 0.003）。两组在硝普钠和乙酰胆碱递增输注时前臂血流（FBF）均增加，但ED组和非ED组的曲线下面积（AUC）相似（分别为p = 0.16和p = 0.17）。我们证明2型糖尿病患者的ED与额外的全身性内皮功能障碍无关。
