Borsook David, Becerra Lino R
P.A.I.N. Group, Brain Imaging Center, Department of Psychiatry, McLean Hospital, Belmont, MA, USA.
Mol Pain. 2006 Sep 18;2:30. doi: 10.1186/1744-8069-2-30.
This review summarizes functional magnetic resonance imaging (fMRI) findings that have informed our current understanding of pain, analgesia and related phenomena, and discusses the potential role of fMRI in improved therapeutic approaches to pain. It is divided into 3 main sections: (1) fMRI studies of acute and chronic pain. Physiological studies of pain have found numerous regions of the brain to be involved in the interpretation of the 'pain experience'; studies in chronic pain conditions have identified a significant CNS component; and fMRI studies of surrogate models of chronic pain are also being used to further this understanding. (2) fMRI studies of endogenous pain processing including placebo, empathy, attention or cognitive modulation of pain. (3) The use of fMRI to evaluate the effects of analgesics on brain function in acute and chronic pain. fMRI has already provided novel insights into the neurobiology of pain. These insights should significantly advance therapeutic approaches to chronic pain.
本综述总结了功能磁共振成像（fMRI）的研究结果，这些结果为我们目前对疼痛、镇痛及相关现象的理解提供了依据，并讨论了fMRI在改进疼痛治疗方法方面的潜在作用。它分为三个主要部分：（1）急性和慢性疼痛的fMRI研究。疼痛的生理学研究发现，大脑中有许多区域参与了对“疼痛体验”的解读；慢性疼痛状况的研究已经确定了一个重要的中枢神经系统成分；慢性疼痛替代模型的fMRI研究也被用于进一步深化这一理解。（2）内源性疼痛处理的fMRI研究，包括安慰剂、共情、注意力或对疼痛的认知调节。（3）使用fMRI评估镇痛药对急性和慢性疼痛脑功能的影响。fMRI已经为疼痛的神经生物学提供了新的见解。这些见解应能显著推进慢性疼痛的治疗方法。
