颗粒淋巴细胞性T细胞型淋巴增殖性疾病（LDGL）具有效应细胞毒性细胞典型的表型模式。

T-cell type lymphoproliferative disease of granular lymphocytes (LDGL) is equipped with a phenotypic pattern typical of effector cytotoxic cells.

作者信息

Baesso Ilenia, Pavan Laura, Boscaro Elisa, Miorin Marta, Facco Monica, Trentin Livio, Agostini Carlo, Zambello Renato, Semenzato Gianpietro

机构信息

Padua University School of Medicine, Department of Clinical and Experimental Medicine, Hematology and Clinical Immunology Branch, University of Padua, Italy.

出版信息

Leuk Res. 2007 Mar;31(3):371-7. doi: 10.1016/j.leukres.2006.06.020. Epub 2006 Sep 18.

DOI:10.1016/j.leukres.2006.06.020

PMID:16982092

Abstract

By analyzing the expression of several cytotoxic markers, killer-immunoglobulin-like receptors (KIRs), CD94/CD159, CD314 and natural cytotoxicity receptors (NCRs), in 22 CD3+ lymphoproliferative disease of granular lymphocyte (LDGL) patients we investigated whether granular lymphocytes (GLs) displayed the phenotype of fully differentiated cytotoxic cells. Our results demonstrate that GLs express a pattern consistent with fully differentiated CTLs. KIRs are expressed only in a fraction of patients (7/22), as is CD94/CD159 (5/22). In conclusion, GLs in CD3+ LDGL patients typically show the phenotype of fully differentiated CTL, whereas the expression of NK receptors does not represent a common feature of the proliferating clone.

摘要

通过分析22例颗粒淋巴细胞型CD3 + 淋巴细胞增殖性疾病（LDGL）患者中几种细胞毒性标志物、杀伤免疫球蛋白样受体（KIR）、CD94/CD159、CD314和自然细胞毒性受体（NCR）的表达，我们研究了颗粒淋巴细胞（GL）是否表现出完全分化的细胞毒性细胞的表型。我们的结果表明，GL表达的模式与完全分化的细胞毒性T淋巴细胞（CTL）一致。KIR仅在部分患者（7/22）中表达，CD94/CD159也是如此（5/22）。总之，CD3 + LDGL患者中的GL通常表现出完全分化的CTL的表型，而NK受体的表达并不是增殖克隆的共同特征。