大颗粒淋巴细胞疾病：新的发病机制线索为创新治疗方法提供了依据。
Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches.
出版信息
Haematologica. 2009 Oct;94(10):1341-5. doi: 10.3324/haematol.2009.012161.
Abstract
The pathogenesis of large granular lymphocytic disorders is now being unravelled. Knowledge of the various cells of origin and the (often viral) drivers of proliferation is emerging. Leukemic transformation involves acquisition of mechanisms to escape death and to continue to proliferate. In this perspective article, Drs. Zambello and Semenzato examine new etiopathogenetic clues as a rationale for innovative therapeutic approaches. See related article on page 1407.
摘要
大颗粒淋巴细胞疾病的发病机制正在被揭示。人们对各种起源细胞以及（通常是病毒）增殖驱动因素的认识正在不断涌现。白血病转化涉及获得逃避死亡和继续增殖的机制。在这篇观点文章中，Zambello 和 Semenzato 博士探讨了新的病因发病学线索，作为创新治疗方法的依据。详见 1407 页相关文章。
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2
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Cancer Res. 2009 May 1;69(9):3986-94. doi: 10.1158/0008-5472.CAN-08-3735. Epub 2009 Apr 14.
3
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