Bozkurt Fatma Yeşim, Yetkin Ay Zuhal, Berker Ezel, Tepe Eser, Akkuş Selami
Süleyman Demirel University, Faculty of Dentistry, Department of Periodontology, Isparta, Turkey.
Cytokine. 2006 Aug;35(3-4):180-5. doi: 10.1016/j.cyto.2006.07.020. Epub 2006 Sep 18.
Cytokines which are produced by host cells play an important role in pathogenesis both rheumatoid arthritis (RA) and chronic periodontitis (CP). In this study, we aim to investigate the levels of Interleukin (IL)-4 and IL-10 in gingival crevicular fluid (GCF). Seventeen patients with CP, 17 patients with RA and 17 healthy controls (HC) were included. The RA group was divided into two groups according to gingival sulcus depths (RA-a: PD < or =3mm, (n=12), RA-b: PD>3mm, (n=5)). For each patient, clinical parameters were recorded. The GCF samples were evaluated by enzyme-linked immunosorbent assay (ELISA) for IL-4 and IL-10 levels. IL-4 levels in the RA-a, RA-b and CP subjects were significantly lower compared to the HC subjects (p<0.05). The mean level of IL-4 in RA-b group was significantly higher than that in CP group (p<0.05). IL-10 mean level in the HC group was higher than those in the other groups (p<0.05). In the RA-a group, higher IL-10 level was found compared to the CP patients (p<0.05). Within the limitations of this preliminary report, it can be concluded that the initiation and progression of periodontal inflammation may be due to a lack or inappropriate response of the anti-inflammatory cytokines in both CP and RA.
宿主细胞产生的细胞因子在类风湿性关节炎（RA）和慢性牙周炎（CP）的发病机制中均发挥着重要作用。在本研究中，我们旨在调查龈沟液（GCF）中白细胞介素（IL）-4和IL-10的水平。研究纳入了17例CP患者、17例RA患者和17名健康对照者（HC）。RA组根据牙龈沟深度分为两组（RA-a：牙周袋深度（PD）≤3mm，（n = 12）；RA-b：PD>3mm，（n = 5））。记录每位患者的临床参数。通过酶联免疫吸附测定（ELISA）评估GCF样本中IL-4和IL-10的水平。与HC组相比，RA-a组、RA-b组和CP组的IL-4水平显著降低（p<0.05）。RA-b组的IL-4平均水平显著高于CP组（p<0.05）。HC组的IL-10平均水平高于其他组（p<0.05）。在RA-a组中，与CP患者相比发现IL-10水平更高（p<0.05）。在本初步报告的局限性范围内，可以得出结论，牙周炎症的发生和进展可能是由于CP和RA中抗炎细胞因子的缺乏或不适当反应所致。
