咖啡酸苯乙酯对胆汁淤积性大鼠细菌移位和肠道损伤的影响。

The effect of caffeic acid phenethyl ester on bacterial translocation and intestinal damage in cholestatic rats.

作者信息

Ara Cengiz, Esrefoglu Mukaddes, Polat Alattin, Isik Burak, Aladag Murat, Gul Mehmet, Ay Selma, Tekerleklioglu M Sait, Yilmaz Sezai

机构信息

Department of General Surgery, Inonu University School of Medicine, 44069 Malatya, Turkey.

出版信息

Dig Dis Sci. 2006 Oct;51(10):1754-60. doi: 10.1007/s10620-006-9130-4.

DOI:10.1007/s10620-006-9130-4

PMID:16983503

Abstract

We investigated the effect of caffeic acid phenethyl ester in rat ileum injury induced by chronic biliary obstruction. Swiss albino rats were divided into three groups: Group 1, sham (n = 7); Group 2, common bile duct ligation (n = 7); and Group 3, common bile duct ligation plus caffeic acid phenethyl ester (n = 7). In the caffeic acid phenethyl ester-treated rats, ileum tissue levels of malondialdehyde and myeloperoxidase were significantly lower than those of the bile duct-ligated rats (P < 0.001). The levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-1alpha in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). The present study demonstrates that intraperitoneal administration of caffeic acid phenethyl ester in bile duct-ligated rats reduces intestinal oxidative stress. This effect may be useful in the preservation of intestinal damage in cholestasis.

摘要

我们研究了咖啡酸苯乙酯对慢性胆道梗阻诱导的大鼠回肠损伤的影响。将瑞士白化大鼠分为三组：第1组，假手术组（n = 7）；第2组，胆总管结扎组（n = 7）；第3组，胆总管结扎加咖啡酸苯乙酯组（n = 7）。在接受咖啡酸苯乙酯治疗的大鼠中，回肠组织中的丙二醛和髓过氧化物酶水平显著低于胆管结扎大鼠（P < 0.001）。咖啡酸苯乙酯组中的肿瘤坏死因子-α、白细胞介素-6和白细胞介素-1α水平显著低于胆管结扎组（分别为P < 0.03、P < 0.01和P < 0.02）。本研究表明，对胆管结扎大鼠腹腔注射咖啡酸苯乙酯可减轻肠道氧化应激。这种作用可能有助于保护胆汁淤积时的肠道损伤。