Bevin Avery A, Steger James, Mannino Stephen
Department of Dermatology, Naval Medical Center San Diego, California, USA.
Cutis. 2006 Aug;78(2):133-6.
Rheumatoid neutrophilic dermatitis (RND) is an infrequent cutaneous manifestation of rheumatoid arthritis (RA). This condition is seen in patients who are both positive and negative for a circulating rheumatoid factor. Histologically, it presents with a neutrophilic dermatosis, characterized by a heavy dermal infiltrate of neutrophils with variable degrees of leukocytoclasis but no vasculitis. We describe the case of a young female with seronegative RA who had concomitant lesions of RND over both elbows. Her lesions appeared as nodules, but RND has been reported as papules and plaques, sometimes with an urticarialike appearance or ulcerations. They are often symmetric. The possibility of RND should be considered in the differential of unusual skin lesions in all patients with RA, as the presentation is quite varied.
类风湿性嗜中性皮病(RND)是类风湿性关节炎(RA)一种罕见的皮肤表现。这种情况在类风湿因子循环阳性和阴性的患者中均可见到。组织学上,它表现为嗜中性皮病,其特征是真皮中有大量嗜中性粒细胞浸润,伴有不同程度的白细胞破碎,但无血管炎。我们描述了一名患有血清阴性RA的年轻女性病例,其双肘均伴有RND病变。她的病变表现为结节,但RND也有报道为丘疹和斑块,有时呈荨麻疹样外观或溃疡。它们通常是对称的。在所有RA患者出现不寻常皮肤病变的鉴别诊断中都应考虑RND的可能性,因为其表现形式多种多样。