Brown T S, Fearneyhough P K, Burruss J B, Callen J P
Department of Medicine, Division of Dermatology, University of Louisville, KY, USA.
J Am Acad Dermatol. 2001 Oct;45(4):596-600. doi: 10.1067/mjd.2001.119031.
Rheumatoid neutrophilic dermatitis (RND) is an unusual cutaneous reaction in patients with rheumatoid arthritis (RA). RND is characterized by symmetric, erythematous papules, plaques, nodules, and urticarial lesions often located over the joints, extensor surfaces of the extremities, or the trunk. This entity demonstrates an intense neutrophilic dermal infiltrate without vasculitis. All patients previously reported with RND had severe RA with relatively high titers of rheumatoid factor when tested. A 67-year-old woman had a 2-month history of multiple, tender, 4 to 8 mm erythematous, crusted papules and nodules that occurred in clusters on her anterior thighs, knees, and legs. She suffered from severe disabling seronegative RA. RND may complicate seronegative RA.
类风湿性嗜中性皮病（RND）是类风湿性关节炎（RA）患者中一种不常见的皮肤反应。RND的特征为对称分布的红斑丘疹、斑块、结节和荨麻疹样损害，常位于关节、肢体伸侧或躯干。该病症表现为强烈的嗜中性粒细胞真皮浸润而无血管炎。既往报道的所有RND患者在检测时均患有严重RA且类风湿因子滴度相对较高。一名67岁女性有2个月病史，其大腿前部、膝盖和腿部出现多个簇状分布的、触痛的4至8毫米红斑、结痂丘疹和结节。她患有严重致残性血清阴性RA。RND可能使血清阴性RA复杂化。
