Ichikawa M M, Murata Y, Higaki Y, Kawashima M, Furuya T, Saito T
Department of Dermatology, Tokyo Women's Medical College, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Eur J Dermatol. 1998 Jul-Aug;8(5):347-9.
Rheumatoid neutrophilic dermatitis (RND) is a rare disorder seen in patients with severe rheumatoid arthritis. We present a 63-year-old Japanese with seropositive rheumatoid arthritis and rheumatoid lung who showed erythematous plaques and papules with pustules on his extremities and buttocks. Histological examination revealed a dense neutrophilic infiltration the upper dermis and neutrophilic abscesses in the dermal papillae. obvious vasculitis was seen. We suggest that RND could be included within the concept of a neutrophilic vascular reaction and that this condition develops through immune complex-mediated and neutrophil-induced vascular damage.
类风湿性嗜中性皮病(RND)是一种在重度类风湿性关节炎患者中出现的罕见病症。我们报告一例63岁血清学阳性的类风湿性关节炎合并类风湿性肺病的日本患者,其四肢和臀部出现伴有脓疱的红斑性斑块和丘疹。组织学检查显示真皮上层有密集的嗜中性粒细胞浸润,真皮乳头有嗜中性粒细胞脓肿,未见明显血管炎。我们认为RND可归入嗜中性粒细胞血管反应的概念范畴,且这种病症是通过免疫复合物介导和嗜中性粒细胞诱导的血管损伤发展而来。