Altinova Alev E, Törüner Füsun B, Aktürk Müjde, Bukan Neslihan, Cakir Nuri, Ayvaz Göksun, Arslan Metin
Department of Endocrinology and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Clin Endocrinol (Oxf). 2006 Oct;65(4):530-5. doi: 10.1111/j.1365-2265.2006.02628.x.
Adiponectin, an adipose tissue-derived hormone, has been reported to have anti-inflammatory and anti-atherogenic effects. The physiological effect of adiponectin on the metabolic changes and its relation with cardiovascular risk factors in thyroid dysfunction states is still not clear. The aim of the study was to evaluate plasma adiponectin level and its relation to cardiovascular risk factors in patients with thyroid dysfunction.
Sixty-seven patients with hypothyroidism, 56 patients with hyperthyroidism and 52 age- and sex-matched euthyroid subjects were enrolled in the study. Adiponectin, C-reactive protein (CRP), homocysteine (Hcy), lipid parameters, Lipoprotein(a) [Lp (a)], Apolipoprotein (Apo) A, Apo B and fibrinogen levels were measured in all subjects. Insulin sensitivity was determined using the Homeostasis Model Assessment (HOMA-IR).
Circulating adiponectin levels were not different between the groups (16.2 +/- 5.0, 15.1 +/- 3.7, 15.9 +/- 4.8 ng/ml; hypothyroid, hyperthyroid, euthyroid group, respectively). Plasma adiponectin levels correlated negatively with body mass index (BMI) and HOMA-IR index and positively with high-density lipoprotein cholesterol (HDL-C) in all groups. There was a significant correlation between adiponectin and CRP levels in both hypothyroid and hyperthyroid groups. In all groups, adiponectin levels did not correlate with age, systolic blood pressure, diastolic blood pressure and thyroid hormones. Multiple regression analysis revealed BMI and HDL-C levels to be the most important predictors of circulating adiponectin levels.
Plasma adiponectin levels are associated with BMI and HDL-C levels in patients with hypothyroidism and hyperthyroidism. But there is not a direct relation of adiponectin with thyroid hormones in these patients.
脂联素是一种由脂肪组织分泌的激素，据报道具有抗炎和抗动脉粥样硬化作用。脂联素对甲状腺功能障碍状态下代谢变化的生理影响及其与心血管危险因素的关系仍不清楚。本研究旨在评估甲状腺功能障碍患者血浆脂联素水平及其与心血管危险因素的关系。
本研究纳入了67例甲状腺功能减退患者、56例甲状腺功能亢进患者以及52例年龄和性别匹配的甲状腺功能正常的受试者。测量了所有受试者的脂联素、C反应蛋白（CRP）、同型半胱氨酸（Hcy）、血脂参数、脂蛋白（a）[Lp（a）]、载脂蛋白（Apo）A、Apo B和纤维蛋白原水平。采用稳态模型评估（HOMA-IR）法测定胰岛素敏感性。
各组间循环脂联素水平无差异（分别为16.2±5.0、15.1±3.7、15.9±4.8 ng/ml；甲状腺功能减退组、甲状腺功能亢进组、甲状腺功能正常组）。在所有组中，血浆脂联素水平与体重指数（BMI）和HOMA-IR指数呈负相关，与高密度脂蛋白胆固醇（HDL-C）呈正相关。甲状腺功能减退组和甲状腺功能亢进组中脂联素与CRP水平之间存在显著相关性。在所有组中，脂联素水平与年龄、收缩压、舒张压和甲状腺激素均无相关性。多元回归分析显示，BMI和HDL-C水平是循环脂联素水平的最重要预测因素。
甲状腺功能减退和甲状腺功能亢进患者的血浆脂联素水平与BMI和HDL-C水平相关。但在这些患者中，脂联素与甲状腺激素无直接关系。
