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甲状腺激素水平与 2 型糖尿病甲状腺功能正常患者糖尿病肾病的关系。

Association between Thyroid Hormone Levels and Diabetic Kidney Disease in Euthyroid Patients with Type 2 Diabetes.

机构信息

Department of Medicine, The 522 Hospital of the Chinese PLA, Luoyang, Henan Province, China.

Department of Endocrinology and Metabolism, The First Affiliated Hospital of Fourth Military Medical University, Xi'an, Shaanxi Province, China.

出版信息

Sci Rep. 2018 Mar 16;8(1):4728. doi: 10.1038/s41598-018-22904-7.

DOI:10.1038/s41598-018-22904-7
PMID:29549262
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5856822/
Abstract

The association between normal thyroid function and diabetic kidney disease (DKD) has gained increasing attention. The present study evaluated the relationship between normal thyroid hormone levels and DKD in type 2 diabetes mellitus (T2DM) patients. A total of 862 type 2 diabetes patients were enrolled in this cross-sectional study in Xian, Shaanxi Province, China. The subjects were evaluated for anthropometric measurements, thyroid function and DKD. Of 862 patients, 246 (28.5%) suffered from DKD, and the prevalence of DKD did not differ between men and women. The prevalence of DKD showed a significantly decreasing trend across the quartiles based on free triiodothyronine (FT3) levels (41.1%, 30.6%, 23.8%, and 18.9%, P < 0.001). In comparison with all participants categorized in the first FT3 quartile group (FT3-Q1) (<4.380), the adjusted odds ratio of DKD in the second FT3 quartile group (FT3-Q2), the third FT3 quartile group (FT3-Q3), and the fourth FT3 quartile group (FT3-Q4) were 0.655(95%CI: 0.406-1.057), 0.493(95%CI: 0.299-0.813), 0.406(0.237-0.697) (P < 0.05). Also, similar results were observed in men. Conversely, none of the FT3 groups was associated with DKD in women. The present study showed that FT3 within normal range was negatively correlated with DKD in T2DM patients.

摘要

甲状腺功能正常与糖尿病肾病（DKD）之间的关系受到越来越多的关注。本研究评估了 2 型糖尿病（T2DM）患者中正常甲状腺激素水平与 DKD 之间的关系。

这项在中国陕西省西安市进行的横断面研究共纳入了 862 名 2 型糖尿病患者。对受试者进行了人体测量学指标、甲状腺功能和 DKD 的评估。在 862 名患者中，246 名（28.5%）患有 DKD，男性和女性的 DKD 患病率没有差异。

根据游离三碘甲状腺原氨酸（FT3）水平，DKD 的患病率在 FT3 四分位组中呈明显下降趋势（41.1%、30.6%、23.8%和 18.9%，P<0.001）。与所有归类于第一 FT3 四分位组（FT3-Q1）（<4.380）的参与者相比，第二 FT3 四分位组（FT3-Q2）、第三 FT3 四分位组（FT3-Q3）和第四 FT3 四分位组（FT3-Q4）的 DKD 调整后比值比分别为 0.655（95%CI：0.406-1.057）、0.493（95%CI：0.299-0.813）和 0.406（0.237-0.697）（P<0.05）。同样，在男性中也观察到了类似的结果。相反，在女性中，FT3 各四分位组均与 DKD 无关。

本研究表明，T2DM 患者正常范围内的 FT3 与 DKD 呈负相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a992/5856822/7ecc2bcdd7d7/41598_2018_22904_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a992/5856822/694b9ccbd78b/41598_2018_22904_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a992/5856822/7ecc2bcdd7d7/41598_2018_22904_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a992/5856822/694b9ccbd78b/41598_2018_22904_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a992/5856822/7ecc2bcdd7d7/41598_2018_22904_Fig2_HTML.jpg

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