Nakamura Satoko, Ichimura Koichi, Sato Yumiko, Nakamura Shigeo, Nakamine Hirokazu, Inagaki Hiroshi, Sadahira Yoshito, Ohshima Koichi, Sakugawa Sumie, Kondo Eisaku, Yanai Hiroyuki, Ohara Nobuya, Yoshino Tadashi
Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Pathol Int. 2006 Oct;56(10):576-83. doi: 10.1111/j.1440-1827.2006.02011.x.
The aim of the present study was to examine the clinicopathological presentations of follicular lymphomas (FL) of the salivary glands, as compared to mucosa-associated lymphoid tissue (MALT) lymphomas. A total of 27 primary salivary gland lymphomas were examined: 6 FL (five, grade 1; one, grade 2); 19 MALT lymphomas; and two diffuse large B-cell lymphomas. The FL patients ranged in age from 24 to 73 years, with a mean of 49 years, which was younger than that of MALT patients (mean: 64 years; P < 0.05). Four of the six FL arose from the submandibular gland, which was the origin of only five out of a total of 19 MALT lymphomas. One FL patient was in clinical stage (CS) IE, two in CS IIE, and two in CS III and IV. As regards the MALT lymphoma patients, 13 (68%) were in CS IE and five (26%) in CS IIE. None of the FL patients had clinical diagnosis of autoimmune disease but eight MALT lymphoma patients had autoimmune disease. The present study found a relatively high incidence of FL in the salivary glands. The observed differences in age of onset, background of autoimmune disease, and lesion site suggests that the pathogenesis of FL may differ from that of MALT lymphoma.
本研究的目的是研究涎腺滤泡性淋巴瘤（FL）与黏膜相关淋巴组织（MALT）淋巴瘤相比的临床病理表现。共检查了27例原发性涎腺淋巴瘤：6例FL（5例1级；1例2级）；19例MALT淋巴瘤；以及2例弥漫性大B细胞淋巴瘤。FL患者年龄在24至73岁之间，平均49岁，比MALT患者（平均64岁；P<0.05）年轻。6例FL中有4例起源于下颌下腺，而下颌下腺仅为19例MALT淋巴瘤中5例的起源部位。1例FL患者处于临床分期（CS）IE期，2例处于CS IIE期，2例处于CS III期和IV期。对于MALT淋巴瘤患者，13例（68%）处于CS IE期，5例（26%）处于CS IIE期。FL患者均无自身免疫性疾病的临床诊断，但8例MALT淋巴瘤患者患有自身免疫性疾病。本研究发现涎腺中FL的发病率相对较高。观察到的发病年龄、自身免疫性疾病背景和病变部位的差异表明，FL的发病机制可能与MALT淋巴瘤不同。
