Kesavachandran C, Singh Vipul K, Mathur N, Rastogi S K, Siddiqui M K J, Reddy M M K, Bharti R S, Khan Asif M
Epidemiology Section, Industrial Toxicology Research Centre, Lucknow, India.
Redox Rep. 2006;11(4):159-62. doi: 10.1179/135100006X116673.
The study was conducted to assess the magnitude of oxidative stress and lung function abnormalities in 34 male pesticide sprayers on exposure to pesticides in mango plantations. Biochemical studies on blood antioxidant enzymes revealed an unchanged glutathione level and increased level of malondialdehyde (P < 0.001), which indicates that pesticide sprayers may have suffered from oxidative stress. Decreased acetyl-cholinesterase levels (P < 0.001) in sprayers compared to the controls suggest inhibition of cholinesterase activity. The present study shows that pesticide toxicity might lead to oxidative stress and airway narrowing resulting in decreased peak expiratory flow rate.
本研究旨在评估34名在芒果种植园接触农药的男性农药喷洒工的氧化应激程度和肺功能异常情况。对血液抗氧化酶的生化研究显示，谷胱甘肽水平未变，但丙二醛水平升高（P < 0.001），这表明农药喷洒工可能遭受了氧化应激。与对照组相比，喷洒工体内乙酰胆碱酯酶水平降低（P < 0.001），提示胆碱酯酶活性受到抑制。本研究表明，农药毒性可能导致氧化应激和气道狭窄，从而使呼气峰值流速降低。
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