Kesavachandran C, Pathak M K, Fareed M, Bihari V, Mathur N, Srivastava A K
Epidemiology Division, Indian Institute of Toxicology Research, (Council of Scientific and Industrial Research), PB No. 80, Lucknow - 226 001, India.
Indian J Occup Environ Med. 2009 Dec;13(3):121-6. doi: 10.4103/0019-5278.58914.
Shop keepers dealing with pesticides are exposed to multiple pesticides that include organophosphates, organochlorines, carbamates, pyrethroids. Hence an exploratory health study was conducted on shopkeepers selling pesticides in urban areas of Lucknow and Barabanki District, Uttar Pradesh, India.
Detailed information regarding socio-economic status, family history, personal habits and work practices were recorded for 20 subjects and controls by the investigator on a pre-tested questionnaire. Clinical examination including neurological studies of the shopkeepers and control subjects was done.
The study revealed significant slowing of motor nerve conduction velocity and low peak expiratory flow rate among shopkeepers as compared to control subjects. Prevalence of significantly higher gastro-intestinal problems was also observed among exposed subjects. Neurological, ocular, cardiovascular and musculo-skeletal symptoms were also found to be higher among shopkeepers. This was not statistically significant. Significantly higher relative risk for sickness related to systems viz., cardio-vasular, genito-urinary, respiratory, nervous and dermal was observed among exposed subjects compared to controls.
These findings provide a prima facie evidence of clinical manifestations because of multiple exposures to pesticides and poor safety culture at work place.
经营农药的店主会接触多种农药,包括有机磷、有机氯、氨基甲酸酯和拟除虫菊酯。因此,在印度北方邦勒克瑙和巴拉班基区的城市地区,对销售农药的店主进行了一项探索性健康研究。
调查员通过预先测试的问卷,记录了20名店主及对照人员的社会经济状况、家族病史、个人习惯和工作方式等详细信息。对店主和对照人员进行了包括神经学检查在内的临床检查。
研究显示,与对照人员相比,店主的运动神经传导速度显著减慢,呼气峰值流速较低。在接触农药的人员中,胃肠道问题的患病率也明显较高。在店主中还发现神经、眼部、心血管和肌肉骨骼症状较多,但无统计学意义。与对照人员相比,接触农药的人员出现与心血管、泌尿生殖、呼吸、神经和皮肤系统相关疾病的相对风险显著更高。
这些发现初步证明了因多次接触农药以及工作场所安全文化不佳而导致的临床表现。