Fine-tuning ER-beta structure with PTMs.
作者信息
Hart Gerald W, Sakabe Kaoru
机构信息
Department of Biological Chemistry, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21205, USA.
出版信息
Chem Biol. 2006 Sep;13(9):923-4. doi: 10.1016/j.chembiol.2006.09.001.
Abstract
Estrogen receptor beta is differentially regulated by alternative O-GlcNAcylation/O-phosphorylation at Ser(16). NMR, CD, and molecular dynamics analyses of model peptides show that these alternative modifications induce different peptide conformations, providing a molecular basis for their differential regulation of protein function.
摘要
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