Ambrosone Christine B, Nesline Mary K, Davis Warren
Department of Epidemiology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
Cancer Epidemiol Biomarkers Prev. 2006 Sep;15(9):1575-7. doi: 10.1158/1055-9965.EPI-06-0628.
The establishment of a biorepository with linkage to clinical and epidemiologic data will provide an invaluable resource for cancer research, including studies of cancer etiology, progression, and prognosis, as well as development of biomarkers for early detection. Developing an infrastructure for a biorepository linked to clinical, pathologic, and epidemiologic data requires significant efforts in strategic planning for efficient means to ascertain, identify, and consent participants, as well as guidelines for blood collection, processing, and storage while maintaining participant privacy rights. In this report, we present an approach to developing a Data Bank and Biorepository at our own institution, with discussion of elements to be considered when establishing such a bank.
建立一个与临床和流行病学数据相关联的生物样本库将为癌症研究提供宝贵资源，包括癌症病因、进展和预后的研究，以及早期检测生物标志物的开发。为与临床、病理和流行病学数据相关联的生物样本库建立基础设施，需要在战略规划方面付出巨大努力，以采取有效手段确定、识别参与者并获得其同意，同时制定血液采集、处理和存储指南，以维护参与者的隐私权。在本报告中，我们介绍了在我们自己的机构开发数据库和生物样本库的方法，并讨论了建立此类库时应考虑的因素。
