Sadek H, Azli N, Wendling J L, Cvitkovic E, Rahal M, Mamelle G, Guillaume J C, Armand J P, Avril M F
Department of Medicine, Institut Gustave Roussy, Saviny le Temple, France.
Cancer. 1990 Oct 15;66(8):1692-6. doi: 10.1002/1097-0142(19901015)66:8<1692::aid-cncr2820660807>3.0.co;2-y.
The authors treated 14 patients with advanced squamous cell carcinoma (SCC) of the skin or lip with one to four cycles of combination chemotherapy consisting of cisplatin by bolus injection, and 5-fluorouracil (5-FU) and bleomycin by continuous 5-day infusion. Objective responses were seen in 11 of the 13 evaluable patients (84%). Four patients had a complete remission (30%) and seven patients, a partial remission (54%). Local control after definitive complementary radiation and/or surgical treatment was achieved in seven patients. Toxic side effects was acceptable; they consisted of nausea and vomiting in all patients, transient skin changes, hematologic (Grade 3/4) abnormalities in four patients, and pulmonary fibrosis in one elderly patient. These results show that this chemotherapy combination could play a role in reducing the tumor mass and in facilitating definitive treatment to obtain better functional and cosmetic results in advanced SCC of the skin.
作者对14例皮肤或唇部晚期鳞状细胞癌（SCC）患者进行了1至4个周期的联合化疗，化疗方案包括大剂量注射顺铂，以及持续5天输注5-氟尿嘧啶（5-FU）和博来霉素。13例可评估患者中有11例（84%）出现客观缓解。4例患者完全缓解（30%），7例患者部分缓解（54%）。7例患者在确定性辅助放疗和/或手术治疗后实现了局部控制。毒性副作用可接受；所有患者均出现恶心和呕吐，4例患者出现短暂皮肤改变、血液学（3/4级）异常，1例老年患者出现肺纤维化。这些结果表明，这种联合化疗在减少肿瘤体积以及促进确定性治疗以在晚期皮肤鳞状细胞癌中获得更好的功能和美容效果方面可能发挥作用。
