放疗、免疫疗法及化疗在局部晚期或转移性皮肤恶性肿瘤治疗中的作用
The Role of Radiation, Immunotherapy, and Chemotherapy in the Management of Locally Advanced or Metastatic Cutaneous Malignancies.
作者信息
Yacoub Irini, Rayn Kareem, Choi J Isabelle, Bakst Richard, Chhabra Arpit, Qian Joshua Y, Johnstone Peter, Simone Charles B
机构信息
New York Proton Center, New York, NY 10035, USA.
Department of Radiation Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA.
出版信息
Cancers (Basel). 2024 Nov 22;16(23):3920. doi: 10.3390/cancers16233920.
INTRODUCTION
Skin cancer impacts a significant proportion of the population. While surgical management is often the mainstay of treatment, advanced or metastatic cutaneous malignancies require additional local and/or systemic therapies.
METHODS
A review of the literature was performed studying the use of radiation therapy, chemotherapy, and immunotherapy for locally advanced or metastatic cutaneous malignancies.
RESULTS
A summary of the present literature on the management of locally advanced or metastatic cutaneous malignancies is presented across cutaneous head and neck basal cell carcinoma, squamous cell carcinoma, melanoma, and Merkel cell carcinoma. The addition of multidisciplinary therapies to resection is often associated with improved outcomes.
CONCLUSION
The management of cutaneous head and neck malignancies requires an approach integrating multiple specialties, to optimize outcomes and minimize toxicities.
引言
皮肤癌影响着相当一部分人群。虽然手术治疗通常是主要的治疗手段，但晚期或转移性皮肤恶性肿瘤需要额外的局部和/或全身治疗。
方法
对有关局部晚期或转移性皮肤恶性肿瘤的放射治疗、化学治疗和免疫治疗的文献进行了综述。
结果
本文总结了目前关于局部晚期或转移性皮肤恶性肿瘤治疗的文献，涉及皮肤头颈基底细胞癌、鳞状细胞癌、黑色素瘤和默克尔细胞癌。在手术切除的基础上增加多学科治疗通常与更好的治疗效果相关。
结论
皮肤头颈恶性肿瘤的治疗需要一种整合多个专业的方法，以优化治疗效果并将毒性降至最低。
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