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手术性迷路切除术后梅尼埃病患者的生活质量评估

Quality-of-life assessment of Ménière's disease patients after surgical labyrinthectomy.

作者信息

Diaz Rodney C, LaRouere Michael J, Bojrab Dennis I, Zappia John J, Sargent Eric W, Shaia Wayne T

机构信息

Michigan Ear Institute, Farmington Hills, Michigan 48334, USA.

出版信息

Otol Neurotol. 2007 Jan;28(1):74-86. doi: 10.1097/01.mao.0000233815.71671.6c.

Abstract

OBJECTIVE

To examine the impact of surgical labyrinthectomy on quality of life of Ménière's disease patients.

STUDY DESIGN

Cross-sectional survey.

SETTING

Otology subspecialty referral center.

PATIENTS

All patients with Ménière's disease who underwent surgical labyrinthectomy between 1998 and 2004 were selected. Fifty-three patients satisfied inclusion criteria. Completed questionnaires were obtained from 44 patients.

INTERVENTION(S): The Ménière's Disease Outcomes Questionnaire is a disease-specific quality-of-life questionnaire. It was used to assess the quality of life of patients before and after surgical labyrinthectomy. The questionnaire encompasses physical, mental, and social well-being domains of quality of life.

MAIN OUTCOME MEASURE(S): Change in total quality-of-life score was used to assess the overall impact of surgical labyrinthectomy on subjective patient outcome. Individual quality-of-life domains were also assessed.

RESULTS

Forty-three of 44 respondents (98%) had improvement in total score after surgery. The one patient who demonstrated deterioration developed latent contralateral disease. Average preoperative and postoperative scores were 34 +/- 14 and 67 +/- 15, respectively (p < 0.001). All questions showed significant improvement with surgery (p < 0.001) except questions pertaining to memory (no change) and hearing loss (nonsignificant decrease in score).

CONCLUSION

This study comprises the first patient-directed assessment of quality-of-life outcomes in Ménière's disease patients after labyrinthectomy. Despite the disadvantage of hearing loss, patients consistently reported significant improvement in all quality-of-life domains and do not report a significant loss of quality of life in terms of their hearing loss. Surgical labyrinthectomy remains a highly effective treatment for Ménière's disease patients.

摘要

目的

探讨手术性迷路切除术对梅尼埃病患者生活质量的影响。

研究设计

横断面调查。

研究地点

耳科专科转诊中心。

患者

选取1998年至2004年间接受手术性迷路切除术的所有梅尼埃病患者。53例患者符合纳入标准。44例患者完成了问卷调查。

干预措施

梅尼埃病结局问卷是一种针对该疾病的生活质量问卷。用于评估手术性迷路切除术前后患者的生活质量。该问卷涵盖生活质量的身体、心理和社会福祉领域。

主要观察指标

生活质量总分的变化用于评估手术性迷路切除术对患者主观结局的总体影响。还对各个生活质量领域进行了评估。

结果

44名受访者中有43名(98%)术后总分有所改善。唯一一名病情恶化的患者出现了潜在的对侧疾病。术前和术后的平均得分分别为34±14和67±15(p<0.001)。除了与记忆相关的问题(无变化)和听力损失相关的问题(得分无显著下降)外,所有问题在手术后均有显著改善(p<0.001)。

结论

本研究首次对梅尼埃病患者迷路切除术后的生活质量结局进行了以患者为导向的评估。尽管存在听力损失的缺点,但患者一致报告在所有生活质量领域均有显著改善,且未因听力损失而报告生活质量有显著下降。手术性迷路切除术仍然是治疗梅尼埃病患者的一种非常有效的方法。

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