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1
Botulinum toxin: poisoning the spastic bladder and urethra.肉毒杆菌毒素:麻痹痉挛性膀胱和尿道
Rev Urol. 2002 Spring;4(2):61-8.
2
Botulinum toxin as a new therapy option for voiding disorders: current state of the art.肉毒杆菌毒素作为治疗排尿障碍的一种新的治疗选择:当前的技术水平
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Effect of single botulinum toxin A injection to the external urethral sphincter for treating detrusor external sphincter dyssynergia in spinal cord injury.单次注射A型肉毒杆菌毒素至尿道外括约肌治疗脊髓损伤所致逼尿肌-外括约肌协同失调的效果
J Rehabil Med. 2008 Oct;40(9):744-8. doi: 10.2340/16501977-0255.
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Single-institution experience in 110 patients with botulinum toxin A injection into bladder or urethra.110例患者膀胱或尿道注射A型肉毒杆菌毒素的单机构经验。
Urology. 2005 Jan;65(1):37-41. doi: 10.1016/j.urology.2004.08.016.
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Botulinum toxin urethral sphincter injection to restore bladder emptying in men and women with voiding dysfunction.注射肉毒杆菌毒素至尿道括约肌以恢复排尿功能障碍男性和女性的膀胱排空。
J Urol. 2001 Apr;165(4):1107-10.
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Arch Phys Med Rehabil. 1990 Jan;71(1):24-6.
7
Botulinum toxin treatment of urethral and bladder dysfunction.肉毒杆菌毒素治疗尿道和膀胱功能障碍。
J Formos Med Assoc. 2003 Jan;102(1):5-11.
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Botulinum toxin in the management of lower urinary tract dysfunction: contemporary update.肉毒杆菌毒素在治疗下尿路功能障碍中的应用:当代进展
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Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients.肉毒杆菌A毒素治疗逼尿肌-括约肌协同失调:24例脊髓损伤患者的前瞻性研究
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Botulinum toxin for the treatment of lower urinary tract symptoms: a review.用于治疗下尿路症状的肉毒杆菌毒素:综述
Neurourol Urodyn. 2005;24(1):2-12. doi: 10.1002/nau.20090.

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2
Urothelial mucosal signaling and the overactive bladder-ICI-RS 2013.尿路上皮黏膜信号传导与膀胱过度活动症——2013年国际尿控学会研究研讨会
Neurourol Urodyn. 2014 Jun;33(5):597-601. doi: 10.1002/nau.22604. Epub 2014 May 16.
3
New frontiers in the treatment of overactive bladder and incontinence.膀胱过度活动症和尿失禁治疗的新前沿
Rev Urol. 2002;4 Suppl 4(Suppl 4):S50-6.
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本文引用的文献

1
BOTULISM. STUDIES ON THE MANNER IN WHICH THE TOXIN OF CLOSTRIDIUM BOTULINUM ACTS UPON THE BODY : II. THE EFFECT UPON THE VOLUNTARY NERVOUS SYSTEM.肉毒中毒。关于肉毒梭菌毒素作用于机体方式的研究:Ⅱ.对随意神经系统的影响。
J Exp Med. 1923 Sep 30;38(4):327-46. doi: 10.1084/jem.38.4.327.
2
The action of botulinum toxin on the neuro-muscular junction.肉毒杆菌毒素对神经肌肉接头的作用。
J Physiol. 1949 Aug;109(1-2):10-24. doi: 10.1113/jphysiol.1949.sp004364.
3
Influence of nerve-ending activity and of drugs on the rate of paralysis of rat diaphragm preparations by Cl. botulinum type A toxin.神经末梢活动及药物对A型肉毒杆菌毒素所致大鼠膈肌标本麻痹速率的影响。
J Physiol. 1962 Feb;160(2):221-33. doi: 10.1113/jphysiol.1962.sp006843.
4
Pharmacology and immunology of botulinum toxin serotypes.肉毒杆菌毒素血清型的药理学与免疫学
J Neurol. 2001 Apr;248 Suppl 1:3-10. doi: 10.1007/pl00007816.
5
Botulinum toxin urethral sphincter injection to restore bladder emptying in men and women with voiding dysfunction.注射肉毒杆菌毒素至尿道括约肌以恢复排尿功能障碍男性和女性的膀胱排空。
J Urol. 2001 Apr;165(4):1107-10.
6
Botulinum-A toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results.肉毒杆菌A毒素治疗脊髓损伤患者逼尿肌反射亢进:抗胆碱能药物的新替代方案?初步结果。
J Urol. 2000 Sep;164(3 Pt 1):692-7. doi: 10.1097/00005392-200009010-00018.
7
Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins.胚胎大鼠背根神经节神经元对肉毒杆菌神经毒素的敏感性。
Toxicon. 2000 Feb;38(2):245-58. doi: 10.1016/s0041-0101(99)00153-1.
8
Long-term efficacy of Botulinum toxin in classical achalasia: a prospective study.肉毒杆菌毒素治疗经典型贲门失弛缓症的长期疗效:一项前瞻性研究。
Am J Gastroenterol. 1999 Dec;94(12):3434-9. doi: 10.1111/j.1572-0241.1999.01605.x.
9
A randomized, double-blind, placebo-controlled trial of botulinum A toxin for severe axillary hyperhidrosis.一项关于A型肉毒杆菌毒素治疗重度腋窝多汗症的随机、双盲、安慰剂对照试验。
Br J Dermatol. 1999 Apr;140(4):677-80. doi: 10.1046/j.1365-2133.1999.02769.x.
10
Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals.A型肉毒杆菌神经毒素中毒后运动终板的功能修复:神经芽与其母端之间突触活动的双相转换
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3200-5. doi: 10.1073/pnas.96.6.3200.

肉毒杆菌毒素:麻痹痉挛性膀胱和尿道

Botulinum toxin: poisoning the spastic bladder and urethra.

作者信息

Smith Christopher P, Somogyi George T, Chancellor Michael B

出版信息

Rev Urol. 2002 Spring;4(2):61-8.

PMID:16985657
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1475967/
Abstract

Botulinum toxin has proven to be a safe and effective therapy for a variety of somatic and autonomic motor disorders. Urologists are now finding clinical success with urethral and bladder injection of this fascinating toxin for detrusor sphincter dyssynergia, conditions of pelvic floor spasticity, and overactive bladder. One cannot deny the ingenuity of man in transforming the lethal toxin of Clostridium botulinum into a modern day therapeutic medicine.

摘要

肉毒杆菌毒素已被证明是治疗各种躯体和自主神经运动障碍的一种安全有效的疗法。泌尿外科医生现在发现,将这种神奇的毒素注射到尿道和膀胱,可成功治疗逼尿肌括约肌协同失调、盆底痉挛状态以及膀胱过度活动症。人们不得不承认人类的聪明才智,能将肉毒梭菌的致命毒素转化为现代治疗药物。