肉毒杆菌毒素：麻痹痉挛性膀胱和尿道
Botulinum toxin: poisoning the spastic bladder and urethra.
作者信息
Smith Christopher P, Somogyi George T, Chancellor Michael B
出版信息
Rev Urol. 2002 Spring;4(2):61-8.
Abstract
Botulinum toxin has proven to be a safe and effective therapy for a variety of somatic and autonomic motor disorders. Urologists are now finding clinical success with urethral and bladder injection of this fascinating toxin for detrusor sphincter dyssynergia, conditions of pelvic floor spasticity, and overactive bladder. One cannot deny the ingenuity of man in transforming the lethal toxin of Clostridium botulinum into a modern day therapeutic medicine.
摘要
肉毒杆菌毒素已被证明是治疗各种躯体和自主神经运动障碍的一种安全有效的疗法。泌尿外科医生现在发现，将这种神奇的毒素注射到尿道和膀胱，可成功治疗逼尿肌括约肌协同失调、盆底痉挛状态以及膀胱过度活动症。人们不得不承认人类的聪明才智，能将肉毒梭菌的致命毒素转化为现代治疗药物。
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本文引用的文献
1
BOTULISM. STUDIES ON THE MANNER IN WHICH THE TOXIN OF CLOSTRIDIUM BOTULINUM ACTS UPON THE BODY : II. THE EFFECT UPON THE VOLUNTARY NERVOUS SYSTEM.肉毒中毒。关于肉毒梭菌毒素作用于机体方式的研究：Ⅱ.对随意神经系统的影响。
J Exp Med. 1923 Sep 30;38(4):327-46. doi: 10.1084/jem.38.4.327.
2
The action of botulinum toxin on the neuro-muscular junction.肉毒杆菌毒素对神经肌肉接头的作用。
J Physiol. 1949 Aug;109(1-2):10-24. doi: 10.1113/jphysiol.1949.sp004364.
3
Influence of nerve-ending activity and of drugs on the rate of paralysis of rat diaphragm preparations by Cl. botulinum type A toxin.神经末梢活动及药物对A型肉毒杆菌毒素所致大鼠膈肌标本麻痹速率的影响。
J Physiol. 1962 Feb;160(2):221-33. doi: 10.1113/jphysiol.1962.sp006843.
4
Pharmacology and immunology of botulinum toxin serotypes.肉毒杆菌毒素血清型的药理学与免疫学
J Neurol. 2001 Apr;248 Suppl 1:3-10. doi: 10.1007/pl00007816.
5
6
Botulinum-A toxin for treating detrusor hyperreflexia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results.肉毒杆菌A毒素治疗脊髓损伤患者逼尿肌反射亢进：抗胆碱能药物的新替代方案？初步结果。
J Urol. 2000 Sep;164(3 Pt 1):692-7. doi: 10.1097/00005392-200009010-00018.
7
Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins.胚胎大鼠背根神经节神经元对肉毒杆菌神经毒素的敏感性。
Toxicon. 2000 Feb;38(2):245-58. doi: 10.1016/s0041-0101(99)00153-1.
8
Long-term efficacy of Botulinum toxin in classical achalasia: a prospective study.肉毒杆菌毒素治疗经典型贲门失弛缓症的长期疗效：一项前瞻性研究。
Am J Gastroenterol. 1999 Dec;94(12):3434-9. doi: 10.1111/j.1572-0241.1999.01605.x.
9
A randomized, double-blind, placebo-controlled trial of botulinum A toxin for severe axillary hyperhidrosis.一项关于A型肉毒杆菌毒素治疗重度腋窝多汗症的随机、双盲、安慰剂对照试验。
Br J Dermatol. 1999 Apr;140(4):677-80. doi: 10.1046/j.1365-2133.1999.02769.x.
10
Functional repair of motor endplates after botulinum neurotoxin type A poisoning: biphasic switch of synaptic activity between nerve sprouts and their parent terminals.A型肉毒杆菌神经毒素中毒后运动终板的功能修复：神经芽与其母端之间突触活动的双相转换
Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3200-5. doi: 10.1073/pnas.96.6.3200.
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