Chao D, Freedland S J, Pantuck A J, Zisman A, Belldegrun A S
Rev Urol. 2001 Spring;3(2):85-93.
The search continues for better tumor markers to improve the rate of detection of transitional cell carcinoma (TCC) more quickly in larger populations and to predict the possibility of disease recurrence. Among several new tests currently being screened, telomerase and hyaluronic acid/hyaluronidase (HA/HAase) have shown sensitivity and specificity equal to or better than cytology, and other promising tumor markers are being investigated. Although no marker has yet replaced the need to perform cystoscopy and cytology, the new tests can minimize the cost and difficulty of screening and long-term surveillance of patients who have or are at risk for bladder cancer.
人们一直在寻找更好的肿瘤标志物，以便在更大规模人群中更快地提高移行细胞癌（TCC）的检出率，并预测疾病复发的可能性。在目前正在筛选的几种新检测方法中，端粒酶和透明质酸/透明质酸酶（HA/HAase）已显示出与细胞学相当或更好的敏感性和特异性，并且正在研究其他有前景的肿瘤标志物。尽管尚无标志物能够取代膀胱镜检查和细胞学检查的必要性，但这些新检测方法可以将膀胱癌患者或有膀胱癌风险患者的筛查及长期监测的成本和难度降至最低。
