Raitanen M P, Marttila T, Kaasinen E, Rintala E, Aine R, Tammela T L
Division of Urology, Department of Pathology, Tampere University Hospital, Tampere, Finland.
J Urol. 2000 Jun;163(6):1689-92.
We compared the sensitivity of the BTA statdagger test, a rapid, noninvasive, qualitative urine test that detects bladder tumor associated antigen (human complement factor H related protein) in urine, to that of voided urine cytology in patients with primary bladder cancer. We also assessed the effect of tumor size, number, histological grade and stage on test sensitivity.
We evaluated 151 patients with newly diagnosed bladder cancer in a prospective multicenter study. A voided urine sample obtained before transurethral bladder tumor resection was divided for culture, cytology and BTA stat testing.
Overall sensitivity of the BTA stat test and urine cytology for detecting primary bladder cancer was 81.5% and 30.3%, respectively (p <0.0001). The sensitivity of each test increased as tumor size, number, histological grade and stage increased.
Sensitivity of the BTA stat test was superior to that of voided urine cytology in all tumor categories. This noninvasive, easy to perform, point of care test may have the potential to replace cytology for diagnosing bladder cancer.
我们比较了BTA statdagger检测（一种快速、无创的定性尿液检测，可检测尿液中的膀胱肿瘤相关抗原（人补体因子H相关蛋白））与原发性膀胱癌患者的晨尿细胞学检查的敏感性。我们还评估了肿瘤大小、数量、组织学分级和分期对检测敏感性的影响。
在一项前瞻性多中心研究中，我们评估了151例新诊断的膀胱癌患者。将经尿道膀胱肿瘤切除术前获得的晨尿样本分为用于培养、细胞学检查和BTA stat检测的样本。
BTA stat检测和尿液细胞学检查检测原发性膀胱癌的总体敏感性分别为81.5%和30.3%（p<0.0001）。随着肿瘤大小、数量、组织学分级和分期的增加，每项检测的敏感性均增加。
在所有肿瘤类别中，BTA stat检测的敏感性均优于晨尿细胞学检查。这种无创、易于执行的即时检测可能有潜力取代细胞学检查用于诊断膀胱癌。
